DEBIO 0932

中文名称： DEBIO 0932

英文名称： Debio 0932 ,CUDC-305

CAS： 1061318-81-7

分子式： C₂₂H₃₀N₆O₂S

分子量： 443

EINECS号：

中文同义词英文同义词

Debio 0932 ,CUDC-305

基本性质

沸点	654.8±65.0 °C(Predicted)
密度	1.32±0.1 g/cm3(Predicted)
溶解度	DMSO:33.0(Max Conc. mg/mL);74.56(Max Conc. mM)
形态	A crystalline solid
酸度系数(pKa)	10.02±0.19(Predicted)

安全信息

CHS信息

生产方法及用途

用途	一种HSP90(热休克蛋白90)抑制剂，对 HSP90α和 HSP90β的IC50值分别为100和103nM。Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.

用途

一种HSP90(热休克蛋白90)抑制剂，对 HSP90α和 HSP90β的IC50值分别为100和103nM。Debio 0932 is a novel heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L), including many non-small cell lung cancer (NSCLC) cell lines which are resistant to standard-of-care (SOC) agents. Debio 0932 potently inhibits tumour growth in subcutaneous xenograft models of a number of solid and haematological malignancies, including models of NSCLC which harbour mutations conferring acquired or primary erlotinib resistance.

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