鲁索利替尼磷酸盐

中文名称：鲁索利替尼磷酸盐

英文名称： Ruxolitinib phosphate

CAS： 1092939-17-7

分子式： C₁₇H₂₁N₆O₄P

分子量： 404

EINECS号：

中文同义词鲁索利替尼磷酸盐英文同义词

Ruxolitinib phosphate

基本性质

熔点	186-190°C
溶解度	DMSO (Slightly), Methanol (Slightly)
形态	Solid
颜色	White to Off-White

安全信息

危险性描述	H301-H361-H373
海关编码	29331990

CHS信息

危险性符号(GHS)	GHS06,GHS08
防范说明	P260-P280-P308+P313

生产方法及用途

用途	一种有效的JAK1/2抑制剂,IC50 分别为3.3 nM/2.8 nM，比JAK3选择性高130倍。 Ruxolitinib is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

用途

一种有效的JAK1/2抑制剂,IC50 分别为3.3 nM/2.8 nM，比JAK3选择性高130倍。
Ruxolitinib is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.