产品名称

英文名称：Nutlin-3

同义词

Nutlin-3、548472-68-0、890090-75-2、nutlin 3、(Rac)-Nutlin-3、4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one、(+/-)-Nutlin3、4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)p

产品性质

CAS编号：890090-75-2

分子式：C30H30Cl2N4O4

分子量：581.49

PubChem编号：216345

英文别名：Nutlin-3|548472-68-0|890090-75-2|nutlin 3|(Rac)-Nutlin-3|4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one|(+/-)-Nutlin3|4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)p

规格或纯度：≥97%

英文名称：Nutlin-3

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg卖完停产，不再备货

产品介绍：Nutlin-3是一种有效的，选择性的Mdm2(依赖环指状的泛素蛋白连接酶和p53)拮抗剂，IC50为90 nM。可稳定p53缺陷的细胞中的p73。Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM; stabilizes p73 in p53-deficient cells

IUPAC Name：4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one

INCHI：InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)

InChi Key：BDUHCSBCVGXTJM-UHFFFAOYSA-N

Canonical SMILES：CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Isomeric SMILES：CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

PubChem CID：216345

溶解性：DMSO 100 mg/mL Water <1 mg/mL Ethanol 30 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装