产品名称

英文名称：Metiamide

同义词

SK&F 92058 、 1-Methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)thiourea、甲硫咪胺 、 甲硫米脲 、 1-甲基-3-(2-(((5-甲基-1H-咪唑-4-基)甲基)硫基)乙基)硫脲

产品性质

CAS编号：34839-70-8

分子式：C9H16N4S2

分子量：244.38

PubChem编号：1548992

别名：甲硫咪胺 | 甲硫米脲 | 1-甲基-3-(2-(((5-甲基-1H-咪唑-4-基)甲基)硫基)乙基)硫脲

英文别名：SK&F 92058 | 1-Methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)thiourea

规格或纯度：≥98%

英文名称：Metiamide

生化机理：Description IC50 Value 0.92uM(Ki with glycolaldehyde as the varied substrate for E3) Metiamide is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drμg cimetidine. in vitro Metiamide is a competitive with aldehyde substrates and noncompetitive with the Human E3 Aldehyde Dehydrogenase coenzyme, binding to both the free E3 isozyme and the enzyme·coenzyme binary complex withK i values of 0.92 μM glycolaldehyde as the varied substrate[1]. Data was got as percentage change in GTPase activity induced by metiamide compared with the GTPase activity stimulated by HA (100 μM)[2]. in vivo Metiamide is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. Metiamide inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Metiamide include an increase in gastric bacterial flora such as nitrate-reducing organisms. Clinical trail

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：甲硫米特 (SK&F 92058) 是组胺H2受体拮抗剂。Metiamide (SK&F 92058) is a histamine H2-receptor antagonist.

IUPAC Name：1-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea

INCHI：InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)

InChi Key：FPBPLBWLMYGIQR-UHFFFAOYSA-N

Canonical SMILES：CC1=C(N=CN1)CSCCNC(=S)NC

Isomeric SMILES：CC1=C(N=CN1)CSCCNC(=S)NC

PubChem CID：1548992

CAS Registry No.：34839-70-8

ChEMBL Ligand：CHEMBL275446

DrugBank Ligand：DB08805

BindingDB Ligand：81468

Wikipedia：Metiamide

GPCRdb Ligand：metiamide

溶解性：(25℃) Water 28.7 mg/mL

产品包装