产品名称

英文名称：Ritonavir

同义词

ritonavir、155213-67-5、Norvir、ABT-538、Abbott 84538、A-84538、ABBOTT-84538、Empetus、Ritomune、Ritovir、Viriton、RTV、ABT 538、DRG-0244、Ritonavirum、Viekirax、CHEBI45409、HSDB 7160、TMC 114r、NSC-693184、UNII-O3J8G9O825、DTXSID1048627、O3J8G9O825、NSC693184、CHEMBL163、1,3-th、利托那韦、N-[(2S,3S,5S)-3-羟基-5-[[(2S)-3-甲基-2-[[甲基-[(2-异丙基-1,3-噻唑-4-基)甲基]氨基甲酰]氨基]丁酰]氨基]-1,6-二苯基-己-2-基]氨基甲酸 5-噻唑基甲基酯

产品性质

CAS编号：155213-67-5

分子式：C37H48N6O5S2

分子量：720.94

MDL号：MFCD00927142

PubChem编号：392622

别名：利托那韦|N-[(2S,3S,5S)-3-羟基-5-[[(2S)-3-甲基-2-[[甲基-[(2-异丙基-1,3-噻唑-4-基)甲基]氨基甲酰]氨基]丁酰]氨基]-1,6-二苯基-己-2-基]氨基甲酸 5-噻唑基甲基酯

英文别名：ritonavir|155213-67-5|Norvir|ABT-538|Abbott 84538|A-84538|ABBOTT-84538|Empetus|Ritomune|Ritovir|Viriton|RTV|ABT 538|DRG-0244|Ritonavirum|Viekirax|CHEBI45409|HSDB 7160|TMC 114r|NSC-693184|UNII-O3J8G9O825|DTXSID1048627|O3J8G9O825|NSC693184|CHEMBL163|1,3-th

规格或纯度：≥98%

英文名称：Ritonavir

生化机理：HIV-1和HIV-2蛋白酶抑制剂（EC50值分别为0.022-0.13和0.16μM）。通过肝酶细胞色素P450-3A4（CYP3A4）阻止蛋白酶抑制剂的代谢。口服具有生物活性。当与洛匹那韦联合使用时，可改善MERS-CoV感染动物模型的预后。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：卖完停产，不再备货

产品介绍：Ritonavir是一种HIV蛋白酶抑制剂，用于治疗HIV感染和AIDS。产品介绍 Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。Ritonavir 也是 SARS-CoV 3CLpro 的抑制剂，IC50 为 1.61 μM。Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4).ApplicationRitonavir has been usedas a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine functionas an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cellsas an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin

ALogP：6

IUPAC Name：1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

INCHI：InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChi Key：NCDNCNXCDXHOMX-XGKFQTDJSA-N

Canonical SMILES：CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O

Isomeric SMILES：CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O

WGK Germany：3

RTECS：XA5310000

PubChem CID：392622

CAS Registry No.：155213-67-5

ChEMBL Ligand：CHEMBL163

Wikipedia：Ritonavir

RCSB PDB Ligand：RIT

PEP：ritonavir

Immunopaedia Search：ritonavir

DrugCentral Ligand：2391

溶解性：溶于DMSO, 最高浓度 (mg/mL) 14.42, 最高浓度(mM) 20 温和加热；溶于ethanol, 最高浓度 (mg/mL) 7.21, 最高浓度(mM) 10

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH351 Suspected of causing cancerH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH302+H312+H332 Harmful if swallowed, in contact with skin or if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P362+P364,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317

产品包装