产品名称

英文名称：Olaparib (AZD2281, Ku-0059436)

同义词

KU-0059436、KU0059436、KU-0059436、4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one、4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one、Lynparza、DTXSID60917988、HMS3、奥拉帕尼

产品性质

CAS编号：763113-22-0

分子式：C24H23FN4O3

分子量：434.46

EC号：642-941-5

PubChem编号：23725625

别名：奥拉帕尼

英文别名：KU-0059436|KU0059436|KU-0059436|4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one|4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one|Lynparza|DTXSID60917988|HMS3

规格或纯度：≥98%

英文名称：Olaparib (AZD2281, Ku-0059436)

生化机理：Olaparib is a potent inhibitor of both PARP-1 and PARP-2, with IC50 = 5 nM and 1 nM, respectively. Olaparib is strongly sensitive to KB2P cells due to suppression of base excision repair by PARP inhibition, which may result in the conversion of single-strand breaks to double-strand breaks during DNA replication, thus activating BRCA2-dependent recombination pathways

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂，IC50为5 nM/1 nM，比对Tankyrase-1的作用强300倍。A potent inhibitor of PARPOlaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-times less effective against tankyrase-1.A potent inhibitor of PARP

ALogP：1.9

IUPAC Name：4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one

INCHI：InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

InChi Key：FDLYAMZZIXQODN-UHFFFAOYSA-N

Canonical SMILES：C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

Isomeric SMILES：C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

关联CAS：763113-22-0

PubChem CID：23725625

NSC Number：747856

MeSH Entry Terms：AZD 2281;AZD-2281;AZD221;AZD2281;Lynparza;olaparib

ChEMBL Ligand：CHEMBL521686

CAS Registry No.：763113-22-0

Wikipedia：Olaparib

RCSB PDB Ligand：09L

DrugCentral Ligand：4907

溶解性：Soluble in DMSO (33 mg/mL), ethanol (1.7 mg/mL), and water (<1 mg/mL) at 25 °C.

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P319

产品包装