产品名称

英文名称：Danoprevir

同义词

DANOPREVIR、850876-88-9、ITMN-191、RO5190591、Danoprevir (ITMN-191)、ITMN 191、Ganovo、Intermune ITMN-191、ITMN B、Danoprevir [USANINN]、UNII-911Z9PCQ5F、RG7227、R7227 cpd、R05190591、911Z9PCQ5F、RO-5190591、R 7227、R-05190591、RG 7227、R7227、[(1S,4R,6S,7Z,14S,18R)-4-(cycl

产品性质

CAS编号：850876-88-9

分子式：C35H46FN5O9S

分子量：731.85

PubChem编号：11285588

英文别名：DANOPREVIR|850876-88-9|ITMN-191|RO5190591|Danoprevir (ITMN-191)|ITMN 191|Ganovo|Intermune ITMN-191|ITMN B|Danoprevir [USANINN]|UNII-911Z9PCQ5F|RG7227|R7227 cpd|R05190591|911Z9PCQ5F|RO-5190591|R 7227|R-05190591|RG 7227|R7227|[(1S,4R,6S,7Z,14S,18R)-4-(cycl

规格或纯度：≥95%

英文名称：Danoprevir

生化机理：Danoprevir(ITMN 191; ITMN-191; R7227; RO5190591; RG7227) is an inhibitor of the NS3/4A protease.Danoprevir (ITMN 191; ITMN-191; R7227; RO5190591; RG7227)is useful for anti-HCV,anti-cancer.Potent orally available peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) (IC 50 = 0.2-3.5 nM). Inhibition effect for HCV genotypes 1A/1B/4/5/6 is ~10-fold higher than 2B/3A. No appreciable inhibition in a panel of 79 other protea

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Danoprevir (ITMN-191, RG7227) 是一种肽类抑制剂，作用于丙型肝炎病毒(HCV)的NS3/4A蛋白酶，IC50为0.2-3.5 nM，抑制HCV 1A/1B/4/5/6基因型比抑制2B/3A基因型效果高10倍左右。

ALogP：3.3

IUPAC Name：[(1S,4R,6S,7Z,14S,18R)-4-(cyclopropylsulfonylcarbamoyl)-14-[(2-methylpropan-2-yl)oxycarbonylamino]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-18-yl] 4-fluoro-1,3-dihydroisoindole-2-carboxylate

INCHI：InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7-/t22-,23-,27+,28+,35-/m1/s1

InChi Key：ZVTDLPBHTSMEJZ-JSZLBQEHSA-N

Canonical SMILES：CC(C)(C)OC(=O)NC1CCCCCC=CC2CC2(NC(=O)C3CC(CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6

Isomeric SMILES：CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@]2(NC(=O)[C@@H]3C[C@H](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6

PubChem CID：11285588

溶解性：DMSO 144 mg/mL Water <1 mg/mL Ethanol 144 mg/mL

产品包装