产品名称

英文名称：Vemurafenib (PLX4032, RG7204)

同义词

1-Propanesulfonamide, N-(3-((5-(4-chlorophenyl)-1H-pyrrolo(2,3-b)pyridin-3-yl)carbonyl)-2,4-difluorophenyl)-、207SMY3FQT、HMS3265M04、STK345998、EX-A053、GPXBXXGIAQBQNI-UHFFFAOYSA-N、HMS3265N04、PLX4032 - Vemurafenib、BCP25783、HSDB 8143、Q423111、RG-7204、1-Propanes、维罗非尼

产品性质

CAS编号：918504-65-1

分子式：C23H18ClF2N3O3S

分子量：489.92

PubChem编号：42611257

别名：维罗非尼

英文别名：1-Propanesulfonamide, N-(3-((5-(4-chlorophenyl)-1H-pyrrolo(2,3-b)pyridin-3-yl)carbonyl)-2,4-difluorophenyl)-|207SMY3FQT|HMS3265M04|STK345998|EX-A053|GPXBXXGIAQBQNI-UHFFFAOYSA-N|HMS3265N04|PLX4032 - Vemurafenib|BCP25783|HSDB 8143|Q423111|RG-7204|1-Propanes

规格或纯度：≥98%

英文名称：Vemurafenib (PLX4032, RG7204)

生化机理：Vemurafenib is a novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM. Has been shown to kill melanoma cells in vitro.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Vemurafenib (PLX4032, RG7204)是一种新型有效的B-Raf V600E抑制剂，IC50为31 nM。A novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM.Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-Raf V600E with IC50 of 31 nM.A novel and potent inhibitor of B-RAFV600E with IC50 of 31 nM.

ALogP：5

IUPAC Name：N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]propane-1-sulfonamide

INCHI：InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

InChi Key：GPXBXXGIAQBQNI-UHFFFAOYSA-N

Canonical SMILES：CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F

Isomeric SMILES：CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F

PubChem CID：42611257

CAS Registry No.：918504-65-1

ChEMBL Ligand：CHEMBL1229517

ChEBI：CHEBI63637

Wikipedia：Vemurafenib

DrugBank Ligand：DB08881

RCSB PDB Ligand：32, 032

PEP：vemurafenib

Reactome Reaction：R-HSA-6802938

Reactome Drug：R-ALL-6802253

DrugCentral Ligand：4185

溶解性：Soluble in DMSO (100 mg/mL), and methanol. Insoluble in ethanol, and water

熔点：260-262°C

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH350 May cause cancerH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P330,P203,P301+P317,P318,P319

产品包装