产品名称

英文名称：Ganetespib (STA-9090)

同义词

Ganetespib、888216-25-9、Ganetespib (STA-9090)、STA-9090、STA9090、STA 9090、Ganetespib [USAN]、Ganetespib(STA-9090)、5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one、Ganetespib (USAN)、3-(2,4-Dihydroxy-5-isop

产品性质

CAS编号：888216-25-9

分子式：C20H20N4O3

分子量：364.4

PubChem编号：135564985

英文别名：Ganetespib|888216-25-9|Ganetespib (STA-9090)|STA-9090|STA9090|STA 9090|Ganetespib [USAN]|Ganetespib(STA-9090)|5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one|Ganetespib (USAN)|3-(2,4-Dihydroxy-5-isop

规格或纯度：≥98%

英文名称：Ganetespib (STA-9090)

生化机理：Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells. Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Ganetespib binds to and inhibits Hsp90, resulting in the proteasomal degradation of oncogenic client proteins, the inhibition of cell proliferation and the elevation of heat shock protein 72 (Hsp72); it may inhibit the activity of multiple kinases, such as c-Kit, EGFR, and Bcr-Abl, which as client proteins depend on functional HsP90 for maintenance. Hsp90, a 90 kDa molecular chaperone upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability and function of "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic .Potent Hsp90 inhibitor (IC 50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of\xa0hematological and solid tumor cell lines\xa0by causing degradation of multiple oncogenic Hsp90 client proteins.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Ganetespib(STA-9090)是含三唑酮的Hsp90抑制剂，在OSA 8细胞中IC50为4 nM。A unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cellsGanetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.A unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells

ALogP：3.1

IUPAC Name：3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one

INCHI：InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)

InChi Key：RVAQIUULWULRNW-UHFFFAOYSA-N

Canonical SMILES：CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O

Isomeric SMILES：CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O

PubChem CID：135564985

溶解性：DMSO 40 mg/mL Water <1 mg/mL Ethanol 9 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装