产品名称

英文名称：RG2833

同义词

RG2833、1215493-56-3、RG-2833、N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide、RGFP 109、RGFP-109、RGFP109、RG2833 (RGFP109)、N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-methylbenzamide、17V14R89EU、N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide、N-[6-(2

产品性质

CAS编号：1215493-56-3

分子式：C20H25N3O2

分子量：339.43

PubChem编号：56654642

英文别名：RG2833|1215493-56-3|RG-2833|N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide|RGFP 109|RGFP-109|RGFP109|RG2833 (RGFP109)|N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-methylbenzamide|17V14R89EU|N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide|N-[6-(2

规格或纯度：≥98%

英文名称：RG2833

生化机理：Description IC50 Value N/A RGFP 109 is a histone deacetylase inhibitor which can attenuate L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset. in vitro N/A in vivo RGFP109 had no acute effects on dyskinesia after single or 6 days once-daily treatment (both P > 0.05). However, one week following cessation of RGFP109, dyskinesia and duration of ON-time with disabling dyskinesia were reduced by 37% and 50%, respectively (both P < 0.05), compared to that seen previously with L-DOPA alone. There was no change in anti-parkinsonian actions of, or ON-time duration afforded by, L-DOPA (P > 0.05) . Clinical trial

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍 RG2833 (RGFP109)是一种大脑渗透性HDAC抑制剂，作用于HDAC1和HDAC3，无细胞试验中IC50分别为60 nM和50 nM。RG2833是组蛋白去乙酰化酶（HDAC）的抑制剂。在神经元细胞中，RG2833增加弗里德赖希共济失调（FXN）的mRNA和蛋白水平，同时改变基因的表观遗传状态。在外周血单核细胞（PBMCs）中，RG2833抑制HDAC的表达，并增加H3K9乙酰化以及患者血液中的FXN mRNA。在源自iPSC的神经元细胞模型中，血浆RG2833（5 μM）最大程度地抑制去乙化酰酶，并上调FXN。结果表明，FXN转录的增加与去乙酰酶活性的抑制间具有良好的相关性，提示RG2833的作用机理通过去乙酰化来实现。

IUPAC Name：N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide

INCHI：InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)

InChi Key：VOPDXHFYDJAYNS-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N

Isomeric SMILES：CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N

PubChem CID：56654642

CAS Registry No.：1215493-56-3

溶解性：insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥8.05 mg/mL in EtOH with gentle warming and ultrasonic

产品包装