产品名称

英文名称：N-myristoyl-D-erythro-sphingosine

同义词

N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetradecanamide 、 N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetradecanamide 、 C14 Cer 、 LMSP02010001 、 MFCD01320386 、 AKOS037645031

产品性质

CAS编号：123408-74-2

分子式：C32H63NO3

分子量：509.848

PubChem编号：5282310

英文别名：N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetradecanamide | N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetradecanamide | C14 Cer | LMSP02010001 | MFCD01320386 | AKOS037645031

规格或纯度：>99%

英文名称：N-myristoyl-D-erythro-sphingosine

生化机理：Ceramides regulate biological processes including proliferation, differentiation and apoptosis.[6] In the cystic fibrosis patients, elevated levels of C14 ceramide is observed. It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio. Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：神经酰胺的合成主要由涉及棕榈酰辅酶A和L-丝氨酸的从头途径驱动，也由通过复杂鞘脂的再循环的挽救途径驱动。神经酰胺转运蛋白Cert介导C14从平滑内质网向高尔基体的转移。神经酰胺合酶CerS6酶参与C14神经酰胺的合成。 Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids. The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi. Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramideC14 Ceramide (d181/140) is suitable for use• as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS2) for ceramide quantification from muscel biopsies• in lipid monolayer preparation for biophysical studies• in the morphological and dimensional evaluation studies

Isomeric SMILES：CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)NC(=O)CCCCCCCCCCCCC)O

关联CAS：34227-72-0

PubChem CID：5282310

产品包装