产品名称

英文名称：MK-591 sodium

同义词

QUIFLAPON SODIUM、147030-01-1、MK591、Quiflapon (sodium)、MK-591、Quiflapon Sodium [USAN]、MK-591 (sodium)、MK 591、321US0I5R6、sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate、Quiflapon sodium (U

产品性质

CAS编号：147030-01-1

分子式：C34H34ClN2NaO3S

分子量：609.15

PubChem编号：23672584

英文别名：QUIFLAPON SODIUM|147030-01-1|MK591|Quiflapon (sodium)|MK-591|Quiflapon Sodium [USAN]|MK-591 (sodium)|MK 591|321US0I5R6|sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate|Quiflapon sodium (U

规格或纯度：≥98%

英文名称：MK-591 sodium

生化机理：MK591 is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. MK591 is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Research of involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model showed that a novel functional role for 5-lipoxygenase activating protein in the pathogenesis of Alzheimer's disease-like amyloidosis, and sμggest that its pharmacological inhibition could provide a novel therapeutic opportunity for Alzheimer's disease. Another research showed 5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Quiflapon sodium (MK-591 sodium) 是选择性的，特异性的 FLAP 抑制剂。Quiflapon sodium 是一种有效的，具有活性的白三烯生物合成 (leukotriene biosynthesis) 抑制剂。诱导细胞凋亡 (apoptosis)。

IUPAC Name：sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoate

INCHI：InChI=1S/C34H35ClN2O3S.Na/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39;/h6-18H,19-21H2,1-5H3,(H,38,39);/q;+1/p-1

InChi Key：YPURUCMVRRNPHJ-UHFFFAOYSA-M

Canonical SMILES：CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)CC5=CC=C(C=C5)Cl)CC(C)(C)C(=O)[O-].[Na+]

Isomeric SMILES：CC(C)(C)SC1=C(N(C2=C1C=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)CC5=CC=C(C=C5)Cl)CC(C)(C)C(=O)[O-].[Na+]

关联CAS：136668-42-3(free base)

PubChem CID：23672584

溶解性：DMSO

敏感性：对湿度敏感

产品包装