产品名称

英文名称：BCTC

同义词

BCTC、393514-24-4、N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide、4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide、C20H25ClN4O、N-(4-(tert-Butyl)phenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide、4-(3-氯-2-吡啶基)-N-[4-叔丁基苯基]-1-哌嗪甲酰胺

产品性质

CAS编号：393514-24-4

分子式：C20H25ClN4O

分子量：372.892

MDL号：MFCD08690556

PubChem编号：9929425

别名：4-(3-氯-2-吡啶基)-N-[4-叔丁基苯基]-1-哌嗪甲酰胺

英文别名：BCTC|393514-24-4|N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide|4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide|C20H25ClN4O|N-(4-(tert-Butyl)phenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

规格或纯度：98%

英文名称：BCTC

生化机理：BTBC is an effective and potent transient receptor potential VR1 (vanilloid-1, TRPV1) channel antagonist. VR1 (TRPV1) is a Capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. Studies show that BTBC and Capsazepine both inhibit the activation of rat VR1 (vanilloid receptor 1), induced with acid or Capsaicin. Other VR1 (TRPV1) antagonists include AMG9810 and SB705498. BCTC is an inhibitor of ANKTM1 and TRPM8.Potent inhibitor of TRPV1 (IC 50 values are 35 and 6 nM for capsaicin and acid-induced activation respectively) . Inhibits TRPM8 (IC 50 = 0.8 μM). Reduces hyperalgesia in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：香草素受体1（TRPV1受体）拮抗; BCTC作用于前列腺癌 (PCa) DU145细胞，有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。An effective and potent TRPV1 channel antagonistBCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.An effective and potent TRPV1 channel antagonist

IUPAC Name：N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

INCHI：InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)

InChi Key：ROGUAPYLUCHQGK-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl

Isomeric SMILES：CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl

WGK Germany：3

PubChem CID：9929425

ChEMBL Ligand：CHEMBL441472

BindingDB Ligand：50133817

CAS Registry No.：393514-24-4

溶解性：Soluble in DMSO (20 mg/ml), ethanol (15 mg/ml with warming), and DMF.

熔点：150-152°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装