产品名称

英文名称：Fluticasone propionate

同义词

FLUTICASONE PROPIONATE、80474-14-2、Flovent、Cutivate、Flixotide、Flonase、Flixonase、Flovent HFA、Flusonal、Fluspiral、Flunase、Flutide、atemur、Asmatil、Axotide、Brethal、Fluinol、Flutivate、Flixotide Disk、Flixotide Disks、Flovent Diskus、Flovent Diskus 50、Flixotide Inhale、丙酸氟替卡松、氟替卡松丙酸酯、(6α,11β,16α,17α)-6,9-二氟-11-羟-16-甲基-3-氧代-17-(1-氧代丙氧基)-雄甾-1,4-二烯-17-硫代羧酸 S-(氟甲基)酯、6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯

产品性质

CAS编号：80474-14-2

分子式：C25H31F3O5S

分子量：500.57

MDL号：MFCD00866007

PubChem编号：444036

别名：丙酸氟替卡松|氟替卡松丙酸酯|(6α,11β,16α,17α)-6,9-二氟-11-羟-16-甲基-3-氧代-17-(1-氧代丙氧基)-雄甾-1,4-二烯-17-硫代羧酸 S-(氟甲基)酯|6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯

英文别名：FLUTICASONE PROPIONATE|80474-14-2|Flovent|Cutivate|Flixotide|Flonase|Flixonase|Flovent HFA|Flusonal|Fluspiral|Flunase|Flutide|atemur|Asmatil|Axotide|Brethal|Fluinol|Flutivate|Flixotide Disk|Flixotide Disks|Flovent Diskus|Flovent Diskus 50|Flixotide Inhale

规格或纯度：≥97%

英文名称：Fluticasone propionate

生化机理：Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (Kd = 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone.Potent, selective glucocorticoid agonist (EC 50 = 3.7 nM). Higher affinity for the glucocorticoid receptor compared to beclomethasone (K d = 0.5 nM). Lipophilic anti-inflammatory agent. Biological effects include eosinophil apoptosis, reduction in mast ce

应用：A high-affinity, selective glucocorticoid receptor agonist.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Fluticasone propionate 是一种合成的皮质类固醇，是Fluticasone的衍生物，用于治疗哮喘和过敏性鼻炎（花粉症）。A high-affinity, selective glucocorticoid receptor agonist.Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever).A high-affinity, selective glucocorticoid receptor agonist.

ALogP：4

IUPAC Name：[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate

INCHI：InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

InChi Key：WMWTYOKRWGGJOA-CENSZEJFSA-N

Canonical SMILES：CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF

Isomeric SMILES：CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF

WGK Germany：2

RTECS：BV7980000

PubChem CID：444036

Reaxy-Rn：6944704

DrugBank Ligand：DB00588

CAS Registry No.：80474-14-2

ChEMBL Ligand：CHEMBL1473

Wikipedia：Fluticasone propionate

Reactome Reaction：R-HSA-9678925

Reactome Drug：R-ALL-9678975

DrugCentral Ligand：1225

溶解性：DMSO 100 mg/mL Water Ethanol 5 mg/mL

比旋光度：31° (C=1,Dioxane)

熔点：275°C(lit.)

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaledH410 Very toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P284,P270,P304+P340,P272,P333+P313,P362+P364,P391,P330,P203,P301+P317,P318,P319,P342+P316

Merck Index：4211

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装