产品名称

英文名称：Cinaciguat

同义词

HY-14181 、 Cinaciguat (BAY 58-2667) 、 Cinaciguat [INNJAN] 、 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoicacid 、 Cinaciguat (JAN/INN) 、 cinaciguatum 、 Z90 、 D07577 、 GEQBPMNDDHGGPJ-UHFFFAOYSA-N 、 NSC-98326 、 4-[[4-carboxybu

产品性质

CAS编号：329773-35-5

分子式：C36H39NO5

分子量：565.70

PubChem编号：9808022

英文别名：HY-14181 | Cinaciguat (BAY 58-2667) | Cinaciguat [INNJAN] | 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoicacid | Cinaciguat (JAN/INN) | cinaciguatum | Z90 | D07577 | GEQBPMNDDHGGPJ-UHFFFAOYSA-N | NSC-98326 | 4-[[4-carboxybu

规格或纯度：≥98%

英文名称：Cinaciguat

生化机理：Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure. Cinaciguat has potent preload- and afterload-reducing effects, increasing cardiac output. Cinaciguat causes potent and sustained fetal pulmonary vasodilation that is aμgmented in the presence of oxidized sGC and speculate that Cinaciguat may have therapeutic potential for severe neonatal pulmonary hypertension.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Cinaciguat 是一种不依赖于一氧化氮的鸟苷酸环化酶 (GC) 活化剂，Kd 值为3.2 nM。Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

ALogP：4.9

IUPAC Name：4-[[4-carboxybutyl-[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid

INCHI：InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41)

InChi Key：WPYWMXNXEZFMAK-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C(C=C1)CCC2=CC=C(C=C2)COC3=CC=CC=C3CCN(CCCCC(=O)O)CC4=CC=C(C=C4)C(=O)O

Isomeric SMILES：C1=CC=C(C=C1)CCC2=CC=C(C=C2)COC3=CC=CC=C3CCN(CCCCC(=O)O)CC4=CC=C(C=C4)C(=O)O

PubChem CID：9808022

CAS Registry No.：329773-35-5

Wikipedia：Cinaciguat

ChEMBL Ligand：CHEMBL1236936

RCSB PDB Ligand：Z90

溶解性：DMSO

产品包装