产品名称

英文名称：Orteronel

同义词

Orteronel、566939-85-3、TAK 700、TAK-700、(S)-Orteronel、(S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide、UE5K2FNS92、TAK700、CHEMBL1921976、566939-85-3 (s-isomer)、6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-meth

产品性质

CAS编号：566939-85-3

分子式：C18H17N3O2

分子量：307.35

PubChem编号：9796590

英文别名：Orteronel|566939-85-3|TAK 700|TAK-700|(S)-Orteronel|(S)-6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide|UE5K2FNS92|TAK700|CHEMBL1921976|566939-85-3 (s-isomer)|6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-meth

规格或纯度：≥99%

英文名称：Orteronel

生化机理：TAK-700 shows potent inhibitory activity against rat, monkey, and human steroid 17,20-lyase inhibitor with IC50 of 54 nM, 27 nM, and 38 nM, respectively. In monkey adrenal cells, TAK-700 inhibits the ACTH stimulated production of DHEA and androstenedione with IC50 of 110 nM and 130 nM, respectively. TAK-700 also potently inhibits DHEA production in human adrenocortical tumor line H295R cells with IC50 of 37 nM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Orteronel(TAK-700)是已进入临床三期的用于治疗去势抵抗性前列腺癌的化合物。A steroid 17,20-lyase inhibitor with efficacy in rat, monkey, and human cells.Orteronel(TAK-700) was selected as a candidate for clinical evaluation. orteronel (TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer.A steroid 17,20-lyase inhibitor with efficacy in rat, monkey, and human cells.

ALogP：1.3

IUPAC Name：6-[(7S)-7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl]-N-methylnaphthalene-2-carboxamide

INCHI：InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1

InChi Key：OZPFIJIOIVJZMN-SFHVURJKSA-N

Canonical SMILES：CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O

Isomeric SMILES：CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)[C@]3(CCN4C3=CN=C4)O

PubChem CID：9796590

溶解性：DMSO ≥60mg/mL;Water <1.2mg/mL;Ethanol ≥60mg/mL

象形图：

信号词：Danger

危险声明：H372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P270,P203,P318,P319

产品包装