产品名称

英文名称：Sphingomyelin (Milk, Bovine)

同义词

C23 Sphingomyelin 、 SM(d181/230) 、 N-(tricosanoyl)-sphing-4-enine-1-phosphocholine 、 Sphingomyelin (Milk, Bovine) 、 N-tricosanoylsphing-4-enine-1-phosphocholine

产品性质

CAS编号：475662-40-9

PubChem编号：46891684

英文别名：C23 Sphingomyelin | SM(d181/230) | N-(tricosanoyl)-sphing-4-enine-1-phosphocholine | Sphingomyelin (Milk, Bovine) | N-tricosanoylsphing-4-enine-1-phosphocholine

规格或纯度：>99%

英文名称：Sphingomyelin (Milk, Bovine)

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thoμght to have a purely structural role, similar to the function of phosphatidylcholine, throμgh intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base. However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts. These membrane microdomains are thoμght to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.Milk SM has been used as a lipid standard.It is also suitable for detecting ceramide in feces and for differential scanning calorimetry.As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base. However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts. These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.

Isomeric SMILES：CCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)[C@@H](/C=C/CCCCCCCCCCCCC)O

PubChem CID：46891684

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