产品名称

英文名称：Gambogic acid

同义词

gambogic acid、2752-65-0、(-)-Gambogic Acid、Gambogic-acid、Guttatic acid、R-gambogic acid、Guttic acid、beta-Guttiferin、Cambogic acid、B''-Guttiferin、GAMBOGICACID、8N585K83U2、.beta.-Guttiferin、(Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut、藤黄酸 A、R,S-藤黄酸

产品性质

CAS编号：2752-65-0

分子式：C38H44O8

分子量：628.75

PubChem编号：9852185

别名：藤黄酸 A|R,S-藤黄酸

英文别名：gambogic acid|2752-65-0|(-)-Gambogic Acid|Gambogic-acid|Guttatic acid|R-gambogic acid|Guttic acid|beta-Guttiferin|Cambogic acid|B''-Guttiferin|GAMBOGICACID|8N585K83U2|.beta.-Guttiferin|(Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut

规格或纯度：≥97% (HPLC)

英文名称：Gambogic acid

生化机理：Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. This natural chemical has shown promising antitumor activity in clinical trials with mice. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively. Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle.Cell-permeable caspase activator (EC 50 = 0.78 - 1.64 µM). Apoptotic agent. Decreases Bcl-2 and increases Bax expression. Potentiates cisplatin -induced apoptosis. Inhibits angiogenesis. Shows antitumor effects in vivo. Orally active.

应用：藤黄酸作为蛋白酶激活和凋亡诱导剂，会捕获细胞周期的G2 / M期，而且造成不可逆。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：不溶于水藤黄酸作为蛋白酶激活和凋亡诱导剂，会捕获细胞周期的G2 / M期，而且造成不可逆。Gambogic acid causes an irreversible arrest in the G2/M phase of the cell cycle. It acts as a caspase activator and apoptosis inducer

IUPAC Name：(Z)-4-[(1S,2S,8R,17S,19R)-12-hydroxy-8,21,21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11,15-pentaen-19-yl]-2-methylbut-2-enoic acid

INCHI：InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1

InChi Key：GEZHEQNLKAOMCA-RRZNCOCZSA-N

Canonical SMILES：CC(=CCCC1(C=CC2=C(C3=C(C(=C2O1)CC=C(C)C)OC45C6CC(C=C4C3=O)C(=O)C5(OC6(C)C)CC=C(C)C(=O)O)O)C)C

Isomeric SMILES：CC(=CCC[C@@]1(C=CC2=C(C3=C(C(=C2O1)CC=C(C)C)O[C@@]45[C@H]6C[C@@H](C=C4C3=O)C(=O)[C@@]5(OC6(C)C)C/C=C(/C)\C(=O)O)O)C)C

WGK Germany：1

RTECS：PB9268200

PubChem CID：9852185

UN Number：1356

溶解性：DMSO ≥100 mg/mL；H2O insoluble;Ethanol100 mg/mL

密度：1.29

沸点：280°C

熔点：81.8°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319

个人防护装备：Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

产品包装