产品名称

英文名称：Disopyramide

同义词

disopyramide、3737-09-5、Dicorantil、Isorythm、Ritmodan、Lispine、Disopiramida、Rythmodan、Rythmodan P、Searle 703、Disopyramidum、Ritmilen、Disopyramidum [INN-Latin]、Dl-disopyramide、Disopiramida [INN-Spanish]、SC 7031、Disopyramide Free Base、(rs)-disopyramide、SC-7031、达舒平、双异丙吡胺,4-(二异丙基氨基)-2-苯基-2-(2-吡啶基)丁酰胺

产品性质

CAS编号：3737-09-5

分子式：C21H29N3O

分子量：339.47

EC号：223-110-2

MDL号：MFCD00057366

PubChem编号：3114

别名：达舒平|双异丙吡胺,4-(二异丙基氨基)-2-苯基-2-(2-吡啶基)丁酰胺

英文别名：disopyramide|3737-09-5|Dicorantil|Isorythm|Ritmodan|Lispine|Disopiramida|Rythmodan|Rythmodan P|Searle 703|Disopyramidum|Ritmilen|Disopyramidum [INN-Latin]|Dl-disopyramide|Disopiramida [INN-Spanish]|SC 7031|Disopyramide Free Base|(rs)-disopyramide|SC-7031|

规格或纯度：98%

英文名称：Disopyramide

运输条件：常规运输

产品介绍：Disopyramide (Dicorantil) 是一种用于研究室性和房性心律失常的 IA 类抗心律失常试剂。Disopyramide 阻断心肌快速内向钠电流 (sodium current)，延长心肌动作电位持续时间。Disopyramide 抑制 HERG 编码的钾通道 (potassium channels)。Disopyramide 也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action

IUPAC Name：4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide

INCHI：InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

InChi Key：UVTNFZQICZKOEM-UHFFFAOYSA-N

Canonical SMILES：CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C

Isomeric SMILES：CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C

WGK Germany：3

PubChem CID：3114

DrugBank Ligand：DB00280

ChEMBL Ligand：CHEMBL517

Wikipedia：Disopyramide

CAS Registry No.：3737-09-5

PEP：disopyramide

DrugCentral Ligand：926

溶解性：Slightly soluble in water

熔点：96°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P270,P330,P203,P301+P317,P318

Merck Index：3360

产品包装