产品名称

英文名称：PP2

同义词

172889-27-9、pp2、PP 2、1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine、AG 1879、1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine、1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine、4-Amino-5-(4-chloropheny

产品性质

CAS编号：172889-27-9

分子式：C15H16ClN5

分子量：301.77

EC号：878-892-3

MDL号：MFCD1568210

PubChem编号：4878

英文别名：172889-27-9|pp2|PP 2|1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine|AG 1879|1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine|1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine|4-Amino-5-(4-chloropheny

规格或纯度：≥98%

英文名称：PP2

生化机理：PP 2 is an effective and selective inhibitor of c-Src family kinases. The inhibitor has been shown to inhibit Lck, FynT, phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). Additionally, PP 2 was reported to inhibit tyrosone kinase-dependent TcR-induced T cell proliferation. PP 2 studies indicate that this agent has demonstrated the ability to activate ERK 1, ERK 2 and p38. Research sμggests that PP 2 may be useful to help identify c-Src family member substrates. MCF-7 cell research shows that PP 2 down regulates the expression of both enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 (PRDX3), and induces apoptosis. PP 2 is an inhibitor of casein kinase I δ and RICK.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PP2(AGL 1879) 是可逆的ATP竞争性的Src家族抑制剂，对p56lck，p59fynT，Hck和Src的IC50分别为4，5，5和100 nM。An effective and selective inhibitor of Src family kinasesPP2, a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.An effective and selective inhibitor of Src family kinases

IUPAC Name：1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine

INCHI：InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)

InChi Key：PBBRWFOVCUAONR-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N

Isomeric SMILES：CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N

关联CAS：172889-27-9

PubChem CID：4878

MeSH Entry Terms：4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo(3,4-d)pyrimidine;AG 1879;AG1879;PP2 cpd;Src family kinase inhibitor PP2

溶解性：DMSO 60 mg/mL Water <1 mg/mL Ethanol 2 mg/mL

密度：1.36

敏感性：对空气敏感，对热敏感

折光率：1.68

沸点：493.54° C at 760 mmHg

熔点：193.32°C

产品包装