产品名称

英文名称：Alvimopan

同义词

2-[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanamido]acetic acid、EN300-7393122、GLYCINE, N-(2-((4-(3-HYDROXYPHENYL)-3,4-DIMETHYL-1-PIPERIDINYL)METHYL)-1-OXO-3-PHENYLPROPYL)-, (3R-((S*),3.ALPHA.,4.ALPHA.))-、DTXSID7023936、UN、爱维莫潘

产品性质

CAS编号：156053-89-3

分子式：C25H32N2O4

分子量：424.53

PubChem编号：5488548

别名：爱维莫潘

英文别名：2-[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanamido]acetic acid|EN300-7393122|GLYCINE, N-(2-((4-(3-HYDROXYPHENYL)-3,4-DIMETHYL-1-PIPERIDINYL)METHYL)-1-OXO-3-PHENYLPROPYL)-, (3R-((S*),3.ALPHA.,4.ALPHA.))-|DTXSID7023936|UN

规格或纯度：≥98%

英文名称：Alvimopan

生化机理：Alvimopan(ADL 8-2698; Entereg; LY 246736) is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, Alvimopan(ADL 8-2698; Entereg; LY 246736) binds to mu-opioid receptors in the gut, thereby reversing opiod-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：25mg、100mg卖完停产，不再备货

产品介绍：Alvimopan is a gastroprokinetic, peripheral-μ-opioid receptor antagonist.A gastroprokinetic, peripheral μ-opioid receptor antagonist.Alvimopan is a gastroprokinetic, peripheral-μ-opioid receptor antagonist.A gastroprokinetic, peripheral μ-opioid receptor antagonist.

IUPAC Name：2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid

INCHI：InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,25+/m0/s1

InChi Key：UPNUIXSCZBYVBB-JVFUWBCBSA-N

Canonical SMILES：CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(CC3=CC=CC=C3)C(=O)NCC(=O)O

Isomeric SMILES：C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)C[C@H](CC3=CC=CC=C3)C(=O)NCC(=O)O

PubChem CID：5488548

CAS Registry No.：156053-89-3

ChEMBL Ligand：CHEMBL270190

DrugBank Ligand：DB06274

Wikipedia：Alvimopan

DrugCentral Ligand：143

RCSB PDB Ligand：NG0, NG0

GPCRdb Ligand：alvimopan

溶解性：DMSO

比旋光度：+46 to +52°, c = 1.0 in DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装