产品名称

英文名称：Tezampanel

同义词

Tezampanel、Tezampanel (anhydrous)、LY-293558、154652-83-2、150131-78-5、Tezampanel [INN]、Tezampanel, anhydrous、LY293558、LY 293558、NGX-424、LY-293,558、6-(2-(1H-Tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid、CHEMBL14935、GA36S2

产品性质

CAS编号：154652-83-2

分子式：C13H21N5O2

分子量：279.34

PubChem编号：127894

英文别名：Tezampanel|Tezampanel (anhydrous)|LY-293558|154652-83-2|150131-78-5|Tezampanel [INN]|Tezampanel, anhydrous|LY293558|LY 293558|NGX-424|LY-293,558|6-(2-(1H-Tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid|CHEMBL14935|GA36S2

英文名称：Tezampanel

生化机理：Tezampanel (LY293558) is a drμg which acts as an antagonist at the AMPA and kainate families of ionotropic glutamate receptors, with selectivity for the GluR5 subtype of the kainate receptor. It has neuroprotective and anticonvulsant effects. The neuroprotective actions may, at least in part, occur by blocking calcium uptake into neurons. Tezampanel has a range of effects which may be useful for medicinal purposes, as well as its applications in scientific research. It suppresses both the withdrawal symptoms from morphine and other opioids, and the development of tolerance, as well as having antihyperalgesic and analgesic effects in its own right. It also has anxiolytic effects in animal studies and has been sμggested as a candidate for the treatment of anxiety in humans. From Wikipedia.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：(3S,4aR,6R,8aR)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid

INCHI：InChI=1S/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1

InChi Key：ZXFRFPSZAKNPQQ-YTWAJWBKSA-N

Canonical SMILES：C1CC2CNC(CC2CC1CCC3=NNN=N3)C(=O)O

Isomeric SMILES：C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CCC3=NNN=N3)C(=O)O

PubChem CID：127894

Wikipedia：Tezampanel

CAS Registry No.：154652-83-2

ChEMBL Ligand：CHEMBL14935

溶解性：DMSO

产品包装