产品名称

英文名称：N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride

同义词

61714-27-0、W-7 HYDROCHLORIDE、N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride、n-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide hydrochloride、W-7 HCL、W 7 (hydrochloride)、W-7 (hydrochloride)、n-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonami

产品性质

CAS编号：61714-27-0

分子式：C16H21ClN2O2S·HCl

分子量：377.33

Beilstein号：6030170

MDL号：MFCD00012559

PubChem编号：124887

英文别名：61714-27-0|W-7 HYDROCHLORIDE|N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride|n-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide hydrochloride|W-7 HCL|W 7 (hydrochloride)|W-7 (hydrochloride)|n-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonami

规格或纯度：≥98.0%(HPLC)

英文名称：N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride

生化机理：CaM和肌球蛋白轻链激酶抑制剂（对于CaM依赖性PDE活性和肌球蛋白轻链激酶，IC 50值分别为28和51μM）。W-5，W-12和W-13类似物。显示出抗增殖作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：W-7 has been reported to be a calmodulin (CaM) antagonist that inhibits Ca2+/calmodulin-regulated enzyme activities. Injection of murine tails with W-7 has demonstrated this agents ability to decrease tolerance to antinociceptive effects, therefore, CaM and its dependent pathways have demonstrated the capacity to play a role in antinociceptive agent tolerance processes. This cell permeable compound has been found to inhibit proliferation of hamster ovary K1 cells. W-7 has also been noted to bind troponin C in the presence of Ca2+ and inhibit striated muscle contractions.A calmodulin (CaM) antagonist and antiproliferative agent.W-7 has been reported to be a calmodulin (CaM) antagonist that inhibits Ca2+/calmodulin-regulated enzyme activities. Injection of murine tails with W-7 has demonstrated this agents ability to decrease tolerance to antinociceptive effects, therefore, CaM and its dependent pathways have demonstrated the capacity to play a role in antinociceptive agent tolerance processes. This cell permeable compound has been found to inhibit proliferation of hamster ovary K1 cells. W-7 has also been noted to bind troponin C in the presence of Ca2+ and inhibit striated muscle contractions.A calmodulin (CaM) antagonist and antiproliferative agent.ApplicationN-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.

IUPAC Name：N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride

INCHI：InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H

InChi Key：OMMOSRLIFSCDBL-UHFFFAOYSA-N

Canonical SMILES：C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCN.Cl

Isomeric SMILES：C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCN.Cl

WGK Germany：3

PubChem CID：124887

溶解性：Soluble in water (Partly miscible), methanol, 100% ethanol (10 mg/ml)(warm), DMSO (25 mg/ml), DMF, ethylene glycol, and 50% ethanol/water (20 mg/ml).

敏感性：对热敏感

熔点：222 °C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装