产品名称

英文名称：WYE-125132 (WYE-132)

同义词

1144068-46-1、WYE-125132、WYE125132、WYE-132、N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea、WYE 125132、CHEMBL601661、WYE-125132 (WYE-132)、1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-y、N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]-N'-甲基脲

产品性质

CAS编号：1144068-46-1

分子式：C27H33N7O4

分子量：519.61

PubChem编号：25260757

别名：N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-D]嘧啶-6-基]苯基]-N'-甲基脲

英文别名：1144068-46-1|WYE-125132|WYE125132|WYE-132|N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea|WYE 125132|CHEMBL601661|WYE-125132 (WYE-132)|1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-y

规格或纯度：≥98%

英文名称：WYE-125132 (WYE-132)

生化机理：WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus.Highly potent, ATP-competitive mTOR inhibitor (IC 50 = 0.19 nM). Inhibits pre-tRNA synthesis. Antiproliferative agent. Shows antitumor effects in vivo. Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：WYE-125132是ATP竞争性mTOR选择性抑制剂，IC50为0.19 nM，对PI3Ks及其相关的hSMG1和ATR抑制性较弱。A highly potent, ATP-competitive, and specific mTOR kinase inhibitorWYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.A highly potent, ATP-competitive, and specific mTOR kinase inhibitor

IUPAC Name：1-[4-[1-(1,4-dioxaspiro[4.5]decan-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-3-methylurea

INCHI：InChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)

InChi Key：QLHHRYZMBGPBJG-UHFFFAOYSA-N

Canonical SMILES：CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7

Isomeric SMILES：CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7

PubChem CID：25260757

溶解性：DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.6

产品包装