产品名称

英文名称：Bardoxolone Methyl

同义词

Bardoxolone methyl、218600-53-4、CDDO-Me、CDDO methyl ester、RTA 402、NSC 713200、CDDO-Methyl ester、RTA-402、RTA402、NSC713200、methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-c

产品性质

CAS编号：218600-53-4

分子式：C32H43NO4

分子量：505.69

PubChem编号：400769

英文别名：Bardoxolone methyl|218600-53-4|CDDO-Me|CDDO methyl ester|RTA 402|NSC 713200|CDDO-Methyl ester|RTA-402|RTA402|NSC713200|methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-c

规格或纯度：≥98%

英文名称：Bardoxolone Methyl

生化机理：Bardoxolone methyl is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2.Synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. Novel therapeutic agent in the t

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Bardoxolone Methyl是IKK抑制剂，具有强效的促凋亡和抗炎活性。Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.

ALogP：6.7

IUPAC Name：methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate

INCHI：InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1

InChi Key：WPTTVJLTNAWYAO-KPOXMGGZSA-N

Canonical SMILES：CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)OC)C

Isomeric SMILES：C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC

PubChem CID：400769

CAS Registry No.：218600-53-4

ChEMBL Ligand：CHEMBL1762621

Wikipedia：Bardoxolone methyl

溶解性：DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装