产品名称

英文名称：AZD8931 (Sapitinib)

同义词

Sapitinib、848942-61-0、AZD8931、AZD-8931、AZD8931 (Sapitinib)、2-(4-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-n-methylacetamide、Sapitinib [INN]、Sapitinib [WHO-DD]、Sapitinib(AZD8931)、Sapitinib (AZD-8931)、CHEMBL2408045、AZ

产品性质

CAS编号：848942-61-0

分子式：C23H25ClFN5O3

分子量：473.93

PubChem编号：11488320

英文别名：Sapitinib|848942-61-0|AZD8931|AZD-8931|AZD8931 (Sapitinib)|2-(4-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-n-methylacetamide|Sapitinib [INN]|Sapitinib [WHO-DD]|Sapitinib(AZD8931)|Sapitinib (AZD-8931)|CHEMBL2408045|AZ

规格或纯度：≥98%

英文名称：AZD8931 (Sapitinib)

生化机理：AZD8931 is an ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC50 values are 4 nM, 3 nM and 4 nM, respectively).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：AZD8931 (Sapitinib)是一种可逆的，ATP竞争性EGFR， ErbB2和ErbB3抑制剂，IC50分别为4 nM， 3 nM和4 nM，作用于NSCLC细胞比Gefitinib或Lapatinib更有效，作用于ErbB家族比作用于MNK1和Flt选择性强100倍。A potent inhibitor of EGFR phosphorylation.AZD8931 is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt.A potent inhibitor of EGFR phosphorylation.

ALogP：4

IUPAC Name：2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide

INCHI：InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29)

InChi Key：DFJSJLGUIXFDJP-UHFFFAOYSA-N

Canonical SMILES：CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC

Isomeric SMILES：CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC

PubChem CID：11488320

ChEMBL Ligand：CHEMBL2408045

CAS Registry No.：848942-61-0

Reactome Reaction：R-HSA-9652264, R-HSA-9665121, R-HSA-9665304

Reactome Drug：R-ALL-9649894

溶解性：Soluble in DMSO (40 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P270,P330,P203,P301+P317,P318,P319

产品包装