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产品详情
产品名称 英文名称:Tideglusib 同义词 Tideglusib、865854-05-3、NP-12、NP031112、4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione、Tideglusib [INN]、NP-031112、NP 031112、Tideglusib(NP-031112)、4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione、Q747Y6TT42、2-(1-naphthalenyl)-4-(pheny 产品性质 CAS编号:865854-05-3 分子式:C19H14N2O2S 分子量:334.39 MDL号:MFCD18633296 PubChem编号:11313622 英文别名:Tideglusib|865854-05-3|NP-12|NP031112|4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione|Tideglusib [INN]|NP-031112|NP 031112|Tideglusib(NP-031112)|4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione|Q747Y6TT42|2-(1-naphthalenyl)-4-(pheny 规格或纯度:≥98% 英文名称:Tideglusib 生化机理:Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models. 储存温度:-20°C储存 运输条件:超低温冰袋运输 备注:5mg、100mg卖完停产,不再备货 产品介绍:Tideglusib(NP-031112)是不可逆的非ATP竞争性GSK-3β抑制剂,IC50为60 nM。Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. ALogP:4.3 IUPAC Name:4-benzyl-2-naphthalen-1-yl-1,2,4-thiadiazolidine-3,5-dione INCHI:InChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2 InChi Key:PMJIHLSCWIDGMD-UHFFFAOYSA-N Canonical SMILES:C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43 Isomeric SMILES:C1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43 WGK Germany:3 PubChem CID:11313622 Wikipedia:Tideglusib CAS Registry No.:865854-05-3 溶解性:DMSO 1 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 产品包装
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