产品名称

英文名称：PD0332991 HCl

同义词

827022-32-2、Palbociclib hydrochloride、Palbociclib HCl、Palbociclib (hydrochloride)、PD 0332991 HCl、Palbociclib (PD-0332991) HCl、PD 0332991 (Palbociclib) HCl、PD 0332991 hydrochloride、PD-0332991 hydrochloride、BKC4F3Q5XL、Palbociclib (monohydrochloride)、6-acety

产品性质

CAS编号：827022-32-2

分子式：C24H29N7O2·HCl

分子量：483.99

PubChem编号：11431660

英文别名：827022-32-2|Palbociclib hydrochloride|Palbociclib HCl|Palbociclib (hydrochloride)|PD 0332991 HCl|Palbociclib (PD-0332991) HCl|PD 0332991 (Palbociclib) HCl|PD 0332991 hydrochloride|PD-0332991 hydrochloride|BKC4F3Q5XL|Palbociclib (monohydrochloride)|6-acety

规格或纯度：≥98%

英文名称：PD0332991 HCl

生化机理：PD 0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 (IC50’s Cdk4 = 11 nM; Cdk6 = 16 nM). PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, and IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells (IC50 = 66 nM), which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. A recent study shows that PD 0332991 could also suppress malignant rhabdoid tumor (MRT) cell lines.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、10mg卖完停产，不再备货

产品介绍：Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂，IC50为11 nM/16 nM，对CDK1/2/5， EGFR， FGFR， PDGFR， InsR等没有抑制活性。Phase 3。A highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2.Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.A highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2.

IUPAC Name：6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride

INCHI：InChI=1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);1H

InChi Key：STEQOHNDWONVIF-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl

Isomeric SMILES：CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl

PubChem CID：11431660

溶解性：Soluble in water (30 mg/ml at 25 °C), DMSO (3 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C).

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338

产品包装