产品名称

英文名称：LUF6000

同义词

LUF6000、890087-21-5、LUF 6000、LUF-6000、2-cyclohexyl-N-(3,4-dichlorophenyl)-3H-imidazo[4,5-c]quinolin-4-amine、CHEMBL475346、2-cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo[4,5-c]quinolin-4-amine、SCHEMBL936823、GTPL9446、DTXSID30470994、BCP25002、BDBM50588808、AKOS

产品性质

CAS编号：890087-21-5

分子式：C22H20Cl2N4

分子量：411.33

PubChem编号：11711282

英文别名：LUF6000|890087-21-5|LUF 6000|LUF-6000|2-cyclohexyl-N-(3,4-dichlorophenyl)-3H-imidazo[4,5-c]quinolin-4-amine|CHEMBL475346|2-cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo[4,5-c]quinolin-4-amine|SCHEMBL936823|GTPL9446|DTXSID30470994|BCP25002|BDBM50588808|AKOS

英文名称：LUF6000

生化机理：LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). LUF6000 was found to be an allosteric enhancer of Emax of structurally diverse agonists at the A3 AR, being more effective for low-Emax agonists than for high-Emax agonists. LUF6000 exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher, and was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. Interestingly, LUF6000 converted a nucleoside A3 AR antagonist MRS542, but not a non-nucleoside antagonist MRS1220, into an agonist.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：2-cyclohexyl-N-(3,4-dichlorophenyl)-3H-imidazo[4,5-c]quinolin-4-amine

INCHI：InChI=1S/C22H20Cl2N4/c23-16-11-10-14(12-17(16)24)25-22-20-19(15-8-4-5-9-18(15)26-22)27-21(28-20)13-6-2-1-3-7-13/h4-5,8-13H,1-3,6-7H2,(H,25,26)(H,27,28)

InChi Key：UWJVRSIGHHSDSJ-UHFFFAOYSA-N

Canonical SMILES：C1CCC(CC1)C2=NC3=C(N2)C(=NC4=CC=CC=C43)NC5=CC(=C(C=C5)Cl)Cl

Isomeric SMILES：C1CCC(CC1)C2=NC3=C(N2)C(=NC4=CC=CC=C43)NC5=CC(=C(C=C5)Cl)Cl

关联CAS：890087-21-5

PubChem CID：11711282

MeSH Entry Terms：LUF 6000;LUF-6000;LUF6000;N-(3,4-dichlorophenyl)-2-cyclohexyl-1H-imidazo(4,5-c)quinolin-4-amine

溶解性：DMSO

产品包装