产品名称

英文名称：CAL-130

同义词

CAL-130、1431697-74-3、2-[(1S)-1-[(2-amino-7H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one、SCHEMBL17238765、DTXSID101118635、HY-16122A、AKOS040732697、CS-1219、NCGC00378554-01、(s)-2-(1-((2-amino-9h-purin-6-yl)amino)ethyl)-5-methyl-3-(o-tol

产品性质

CAS编号：1431697-74-3

分子式：C23H22N8O

分子量：426.47

PubChem编号：71576676

英文别名：CAL-130|1431697-74-3|2-[(1S)-1-[(2-amino-7H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one|SCHEMBL17238765|DTXSID101118635|HY-16122A|AKOS040732697|CS-1219|NCGC00378554-01|(s)-2-(1-((2-amino-9h-purin-6-yl)amino)ethyl)-5-methyl-3-(o-tol

英文名称：CAL-130

生化机理：CAL-130 is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kγ/δ as therapy for T cell acute lymphoblastic leukemia (T-ALL). In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：2-[(1S)-1-[(2-amino-7H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one

INCHI：InChI=1S/C23H22N8O/c1-12-7-4-5-10-16(12)31-21(28-15-9-6-8-13(2)17(15)22(31)32)14(3)27-20-18-19(26-11-25-18)29-23(24)30-20/h4-11,14H,1-3H3,(H4,24,25,26,27,29,30)/t14-/m0/s1

InChi Key：PUYVJBBSBPUKBT-AWEZNQCLSA-N

Canonical SMILES：CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)C(C)NC4=NC(=NC5=C4NC=N5)N

Isomeric SMILES：CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)[C@H](C)NC4=NC(=NC5=C4NC=N5)N

PubChem CID：71576676

溶解性：DMSO

产品包装