产品名称

英文名称：RGFP966

同义词

RGFP966、1357389-11-7、1396841-57-8、RGFP 966、(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide、RGFP-966、CHEMBL4078477、(E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide、RGFP966 Racemate、GTPL7500、SC

产品性质

CAS编号：1396841-57-8

分子式：C21H19FN4O

分子量：362.4

PubChem编号：56650312

英文别名：RGFP966|1357389-11-7|1396841-57-8|RGFP 966|(E)-N-(2-amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide|RGFP-966|CHEMBL4078477|(E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide|RGFP966 Racemate|GTPL7500|SC

规格或纯度：≥98%

英文名称：RGFP966

生化机理：RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 80 nM and no inhibition of any other HDACs at concentrations up to 15 μM. In mouse studies, RGFP966 facilitated extinction of cocaine-seeking behavior and enhanced long-term object memory acquisition and consolidation. In a rat study, RGFP966 ameliorated amyloid-β oligomer-induced synaptic plasticity impairment. RGFP966 was also found to reduce proliferation and inducd differentiation in mouse lymphoid and myeloid malignancies.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC.

IUPAC Name：(E)-N-(2-amino-4-fluorophenyl)-3-[1-[(E)-3-phenylprop-2-enyl]pyrazol-4-yl]prop-2-enamide

INCHI：InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4+,11-8+

InChi Key：BLVQHYHDYFTPDV-VCABWLAWSA-N

Canonical SMILES：C1=CC=C(C=C1)C=CCN2C=C(C=N2)C=CC(=O)NC3=C(C=C(C=C3)F)N

Isomeric SMILES：C1=CC=C(C=C1)/C=C/CN2C=C(C=N2)/C=C/C(=O)NC3=C(C=C(C=C3)F)N

关联CAS：1357389-11-7

PubChem CID：56650312

MeSH Entry Terms：RGFP966

溶解性：DMSO 72 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装