产品名称

英文名称：Tyrphostin 23

同义词

Tyrphostin 23、118409-57-7、Tyrphostin A23、AG 18、RG-50810、AG-18、2-(3,4-dihydroxybenzylidene)malononitrile、(3,4-Dihydroxybenzylidene)malononitrile、2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile、ag18、AG-18 (Tyrphostin 23)、RV0GCD31OJ、DTXSID9045215、Tyrpho

产品性质

CAS编号：118409-57-7

分子式：C10H6N2O2

分子量：186.17

MDL号：MFCD00133899

PubChem编号：2052

英文别名：Tyrphostin 23|118409-57-7|Tyrphostin A23|AG 18|RG-50810|AG-18|2-(3,4-dihydroxybenzylidene)malononitrile|(3,4-Dihydroxybenzylidene)malononitrile|2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile|ag18|AG-18 (Tyrphostin 23)|RV0GCD31OJ|DTXSID9045215|Tyrpho

规格或纯度：≥98%

英文名称：Tyrphostin 23

生化机理：Tyrphostin A23, also known as tyrphostin-23, belongs to a novel class of low molecular weight proteins that inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb-IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. In human and rat adrenocrotical cell studies tyrphostin-A23 can improved steroid-hormone secretion. Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

应用：Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AG-18(RG-50810; Tyrphostin A23)抑制EGFR，IC50为40 μM。Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils。AG-18 inhibits EGFR with IC50 of 35 μM.Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils。

IUPAC Name：2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile

INCHI：InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

InChi Key：VTJXFTPMFYAJJU-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C=C1C=C(C#N)C#N)O)O

Isomeric SMILES：C1=CC(=C(C=C1C=C(C#N)C#N)O)O

WGK Germany：3

PubChem CID：2052

溶解性：DMSO 37 mg/mL Water <1 mg/mL Ethanol 37 mg/mL

密度：1.4

敏感性：对热敏感

折光率：1.7

沸点：~421.15° C at 760 mmHg

熔点：222 °C(dec.)

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH371 May cause damage to organs

预防措施声明：P405,P501,P264,P260,P270,P308+P316,P319

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装