产品名称

英文名称：H-1152

同义词

H-1152、451462-58-1、(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE、H-1152P、CHEBI88220、4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline、(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline、H1152、dimethylfas

产品性质

CAS编号：451462-58-1

分子式：C16H21N3O2S

分子量：319.42

PubChem编号：448043

英文别名：H-1152|451462-58-1|(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE|H-1152P|CHEBI88220|4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline|(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline|H1152|dimethylfas

规格或纯度：98%

英文名称：H-1152

生化机理：H-1152 is a selective ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor, cell permeable, highly specific, and potent (Ki = 1.6 nM). Exhibits weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27mM for PKC and 10.1 mM for MLCK) and is more potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid and inhibits EP3-stimulated NO formation. H-1152 . dihydrochloride prevents fragmentation of apoptotic cells. Relieves neuropathic pain.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：H-1152是特异的高活性Rho激酶抑制剂，可渗透入细胞膜，Ki为1.6 nM，对其它丝氨酸/苏氨酸激酶抑制性极低。A cell permeable, highly specific, and potent ATP-competitive inhibitor of ρ-kinase inhibitor。H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.A cell permeable, highly specific, and potent ATP-competitive inhibitor of ρ-kinase inhibitor。

IUPAC Name：4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline

INCHI：InChI=1S/C16H21N3O2S/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3/t13-/m0/s1

InChi Key：AWDORCFLUJZUQS-ZDUSSCGKSA-N

Canonical SMILES：CC1CNCCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C

Isomeric SMILES：C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C

PubChem CID：448043

溶解性：25°C DMSO

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH302 Harmful if swallowedH318 Causes serious eye damage

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P305+P354+P338,P317,P332+P317,P319

产品包装