产品名称

英文名称：Purmorphamine

同义词

Purmorphamine、483367-10-8、Shh Signaling Antagonist VI、2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine、Purmorphamine [MI]、Purmorphamine (GMP)、9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine、PB12M2F8KY、CHEMBL1221984、CH、9-环己基-N-[4-(4-吗啉基)苯基]-2-(1-萘氧基)-9H-嘌呤-6-胺

产品性质

CAS编号：483367-10-8

分子式：C31H32N6O2

分子量：520.62

PubChem编号：5284329

别名：9-环己基-N-[4-(4-吗啉基)苯基]-2-(1-萘氧基)-9H-嘌呤-6-胺

英文别名：Purmorphamine|483367-10-8|Shh Signaling Antagonist VI|2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine|Purmorphamine [MI]|Purmorphamine (GMP)|9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine|PB12M2F8KY|CHEMBL1221984|CH

规格或纯度：≥98%

英文名称：Purmorphamine

生化机理：Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo.Smoothened (Smo) receptor agonist (EC 50 ~ 1\xa0μM). Induces osteogenesis in mouse mesenchymal progenitor cells . When combined with BMP-4, can transdifferentiate pre-adipocytes\xa0 and myoblasts\xa0 into osteoblasts.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Purmorphamine与Smo拮抗剂竞争性结合到Smoothened，并激活Smoothened，IC50约为1.5 μM，也诱导成骨细胞分化，EC50为1μM。An activator of the hedgehog (Hh) signaling pathway.Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.An activator of the hedgehog (Hh) signaling pathway.

IUPAC Name：9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine

INCHI：InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

InChi Key：FYBHCRQFSFYWPY-UHFFFAOYSA-N

Canonical SMILES：C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7

Isomeric SMILES：C1CCC(CC1)N2C=NC3=C(N=C(N=C32)OC4=CC=CC5=CC=CC=C54)NC6=CC=C(C=C6)N7CCOCC7

WGK Germany：3

PubChem CID：5284329

CAS Registry No.：483367-10-8

ChEMBL Ligand：CHEMBL1221984

GPCRdb Ligand：purmorphamine

溶解性：Soluble in DMSO (10 mM), DMF (~20 mg/ml), DMFPBS(pH 7.2) (11) (~0.25 mg/ml), and chloroform.

产品包装