产品名称

英文名称：Elesclomol (STA-4783)

同义词

STA-4783、伊利司莫

产品性质

CAS编号：488832-69-5

分子式：C19H20N4O2S2

分子量：400.52

PubChem编号：300471

别名：伊利司莫

英文别名：STA-4783

规格或纯度：≥98%

英文名称：Elesclomol (STA-4783)

生化机理：Elesclomol significantly induces the expression of heat shock stress response genes and metallothionein genes, a signature transcription profile indicative of oxidative stress in Hs294T cells。Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 with IC50 of 110 nM, 24 nM and 9 nM, respectively.Elesclomol induces copper-dependent ROS generation and cytoxicity in yeast.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：100mg卖完停产，不再备货

产品介绍：Elesclomol (STA-4783)是新型氧化应激诱导剂，能促肿瘤细胞凋亡。Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells. Phase 3.

IUPAC Name：1-N',3-N'-bis(benzenecarbonothioyl)-1-N',3-N'-dimethylpropanedihydrazide

INCHI：InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)

InChi Key：BKJIXTWSNXCKJH-UHFFFAOYSA-N

Canonical SMILES：CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2

Isomeric SMILES：CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2

PubChem CID：300471

溶解性：DMSO ≥78mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

产品包装