产品名称

英文名称：Resorufin ethyl ether

同义词

7-ER、7-Ethoxy-3H-phenoxazin-3-one、SCHEMBL104497、FT-0668125、UNII-59AF853SW7、BDBM21360、J-100239、59AF853SW7、HY-D0145、AS-59402、CHEBI34480、RESORUFINETHYLETHER、Q27116097、Resorufinethyl ether、7-Ethoxyresorufin、3H-Phenoxazin-3-one, 7-ethoxy-、7-Ethoxyphenoxazone、7-乙氧基resorufin

产品性质

CAS编号：5725-91-7

分子式：C14H11NO3

分子量：241.24

Beilstein号：225973

MDL号：MFCD00037661

PubChem编号：3294

别名：7-乙氧基resorufin

英文别名：7-ER|7-Ethoxy-3H-phenoxazin-3-one|SCHEMBL104497|FT-0668125|UNII-59AF853SW7|BDBM21360|J-100239|59AF853SW7|HY-D0145|AS-59402|CHEBI34480|RESORUFINETHYLETHER|Q27116097|Resorufinethyl ether|7-Ethoxyresorufin|3H-Phenoxazin-3-one, 7-ethoxy-|7-Ethoxyphenoxazone|

规格或纯度：≥95% (UV)

英文名称：Resorufin ethyl ether

生化机理：荧光微粒体脱烷基酶和CYP450底物。产生红色荧光染料试卤灵（Ex / Em 571/585 nm）。适用于xA0区分CYP同工酶1A1和1A2。

应用：7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thoμght to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.

IUPAC Name：7-ethoxyphenoxazin-3-one

INCHI：InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3

InChi Key：CRCWUBLTFGOMDD-UHFFFAOYSA-N

Canonical SMILES：CCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2

Isomeric SMILES：CCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2

PubChem CID：3294

溶解性：Soluble in DMSO (5 mg/mL), ethanol (5 mg/mL), chloroform, dichloromethane, DMF (5 mg/mL), alcohols, and methanol. Insoluble in water.

产品包装