产品名称

英文名称：Retinoic acid

同义词

Retinoic acid、tretinoin、302-79-4、all-trans-Retinoic acid、Vitamin A acid、trans-Retinoic acid、ATRA、Renova、Retin-A、Vesanoid、Aberel、Eudyna、Airol、All-trans Retinoic Acid、all-trans-Vitamin A acid、Dermairol、Aknefug、Aknoten、Atralin、Cordes vas、Epi-aberel、TRETINON、3,7-二甲基-9-(2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸、维他命A酸、维甲酸、维A酸、视黄酸

产品性质

CAS编号：302-79-4

分子式：C20H28O2

分子量：300.44

Beilstein号：2057223

EC号：206-129-0

MDL号：MFCD00001551

PubChem编号：444795

别名：3,7-二甲基-9-(2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸|维他命A酸|维甲酸|维A酸|视黄酸

英文别名：Retinoic acid|tretinoin|302-79-4|all-trans-Retinoic acid|Vitamin A acid|trans-Retinoic acid|ATRA|Renova|Retin-A|Vesanoid|Aberel|Eudyna|Airol|All-trans Retinoic Acid|all-trans-Vitamin A acid|Dermairol|Aknefug|Aknoten|Atralin|Cordes vas|Epi-aberel|TRETINON|

规格或纯度：98%

英文名称：Retinoic acid

生化机理：Description IC50 Value N/A All-trans retinoic acid (ATRA) has been widely investigated for treatments of many cancers including prostate cancer. in vitro ATRA was able to induce the growth arrest and to increase HOXB13 expression in AR?prostate cancer cells. Both EZH2 and DNMT3b participated in the repression of HOXB13 expression throμgh an epigenetic mechanism involving DNA and histone methylation modifications[1]. ATRA could upregulate HOXB13 throμgh decreasing EZH2 and DNMT3b expressions and reducing their interactions with the HOXB13 promoter[1]. in vivo Earlier studies revealed that treatment of leukemic cells with ATRA resulted in the apoptosis, presumably secondary to the differentiation process. Since ATRA can rectify aberrant cell growth and induce apoptosis, it has been widely investigated in preclinical and clinical trials for the treatment of many cancer types, including early gastric cancer and prostate cancer . In AR? and drμg resistant DU145 prostate cancer cells, ATRA was demonstrated to increase the sensitivity of cells to anticancer agent docetaxel[1]. All-trans retinoic acid (ATRA) induces clinical remission in APL patients by enhancing the rapid differentiation of APL cells and the clearance of PML-RARα, APL's hallmark oncoprotein[2]. Clinical trial N/A.Vitamin A metabolite. Induces apoptosis, shows antimitotic and antitumor activity. Differentiates various stem cells and neural progenitor cells.\xa03D Growth matrix component used in kidney organoid generation.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：不溶于水，溶于乙醚、DMSO (25 mg/ml)；微溶于乙醇和氯仿。 维生素A酸(ATRA) 是一种维生素A酸受体(RAR)和Retinoid X 受体(RXR)的配体，结合上RAR 和 RXR作为转导因子，调控正常细胞和肿瘤细胞的生长和分化。细胞色素P450 (CYPs) 催化ATRA的羟基化；维生素A酸引导胚胎干细胞(embryonic stem cells) 演变成神经元。all?trans?Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

ALogP：6.3

IUPAC Name：(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

INCHI：InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

InChi Key：SHGAZHPCJJPHSC-YCNIQYBTSA-N

Canonical SMILES：CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C

Isomeric SMILES：CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C

WGK Germany：2

RTECS：VH6475000

PubChem CID：444795

Reaxy-Rn：2057223

溶解性：Soluble in ethanol, acetate, dimethyl formamide, dimethyl sulfoxide, chloroform, methanol, acetone and dichloromethane. Insoluble in water and ether.

密度：1.011

敏感性：对空气、光线敏感

熔点：180-181°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

Merck Index：8165

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

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