产品名称

英文名称：Trametinib (GSK1120212)

同义词

JTP 74057、GSK1120212、N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide、SCHEMBL170938、TMT212、TMT-212、AM90271、BCPP000218、EX-A022、NSC800956、NSC-800956、UNII-SW60NG75EN、曲美替尼

产品性质

CAS编号：871700-17-3

分子式：C26H23FIN5O4

分子量：615.39

PubChem编号：11707110

别名：曲美替尼

英文别名：JTP 74057|GSK1120212|N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide|SCHEMBL170938|TMT212|TMT-212|AM90271|BCPP000218|EX-A022|NSC800956|NSC-800956|UNII-SW60NG75EN

规格或纯度：≥98%

英文名称：Trametinib (GSK1120212)

生化机理：Trametinib is an allosteric reversible, selective MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：500mg卖完停产，不再备货

产品介绍：Trametinib (GSK1120212)是一种高特异性的，有效的MEK1/2抑制剂，IC50为0.92 nM/1.8 nM，对c-Raf， B-Raf， ERK1/2没有抑制活性。An allosteric inhibitor of MEK1/MEK2.Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.An allosteric inhibitor of MEK1/MEK2.

ALogP：3.4

IUPAC Name：N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide

INCHI：InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

InChi Key：LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Canonical SMILES：CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5

Isomeric SMILES：CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5

PubChem CID：11707110

ChEMBL Ligand：CHEMBL2103875

CAS Registry No.：871700-17-3

Wikipedia：Trametinib

DrugBank Ligand：DB08911

PEP：trametinib

RCSB PDB Ligand：QOM

Reactome Reaction：R-HSA-9657599

Reactome Drug：R-ALL-9653120

DrugCentral Ligand：4802

溶解性：Soluble in DMSO (100 mg/mL at 25 °C), water (<1 mg/mL at 25 °C), ethanol (<1 mg/mL at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (15 mg/ml).

象形图：

信号词：Danger

危险声明：H317 May cause an allergic skin reactionH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P270,P272,P333+P313,P362+P364,P203,P318,P319

产品包装