产品名称

英文名称：CHIR-124

同义词

CHIR-124、405168-58-3、CHIR124、CHIR 124、(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one、4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One、5K64W8EU3E、CHEMBL377312、2(1H)-Quinoli

产品性质

CAS编号：405168-58-3

分子式：C23H22ClN5O

分子量：419.91

PubChem编号：135399748

英文别名：CHIR-124|405168-58-3|CHIR124|CHIR 124|(S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one|4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One|5K64W8EU3E|CHEMBL377312|2(1H)-Quinoli

规格或纯度：≥99%

英文名称：CHIR-124

生化机理：CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. Chk1 kinase is a critical regulator of both the S and G2/M phase cell cycle checkpoints in response to DNA damage. CHIR-124 has been shown that inhibitors of chk1 can selectively sensitize tumor cells with mutant p53 to genotoxic agents.Novel and\xa0potent Chk1 inhibitor (IC 50 = 0.3 nM), 2,000-fold more potent than Chk2 (IC 50 = 0.7 μM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：CHIR-124是一种新型有效的Chk1抑制剂，无细胞试验中IC50为0.3 nM。比作用于Chk2选择性高2000倍，比作用于CDK2/4和Cdc2活性高500到5000倍。CHIR-124 is an effective Chk1 inhibitor (IC50 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.

IUPAC Name：4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1H-benzimidazol-2-yl)-6-chloro-1H-quinolin-2-one

INCHI：InChI=1S/C23H22ClN5O/c24-14-5-6-16-15(11-14)21(25-19-12-29-9-7-13(19)8-10-29)20(23(30)28-16)22-26-17-3-1-2-4-18(17)27-22/h1-6,11,13,19H,7-10,12H2,(H,26,27)(H2,25,28,30)/t19-/m1/s1

InChi Key：MOVBBVMDHIRCTG-LJQANCHMSA-N

Canonical SMILES：C1CN2CCC1C(C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5

Isomeric SMILES：C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5

PubChem CID：135399748

ChEMBL Ligand：CHEMBL377312

CAS Registry No.：405168-58-3

BindingDB Ligand：50185219

溶解性：DMSO 7 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装