产品名称

英文名称：PD98059

同义词

167869-21-8、PD98059、PD 98059、2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one、2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one、PD-98059、PD 98,059、2-(2-amino-3-methoxyphenyl)chromen-4-one、2'-AMINO-3'-METHOXYFLAVONE、4H-1-Benzopyran-4-one, 2-(2-Amino-3-methoxyp、PD-98059、2-(2-氨基-3-甲氧苯基)色酮

产品性质

CAS编号：167869-21-8

分子式：C16H13NO3

分子量：267.28

MDL号：MFCD00671789

PubChem编号：4713

别名：PD-98059|2-(2-氨基-3-甲氧苯基)色酮

英文别名：167869-21-8|PD98059|PD 98059|2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one|2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one|PD-98059|PD 98,059|2-(2-amino-3-methoxyphenyl)chromen-4-one|2'-AMINO-3'-METHOXYFLAVONE|4H-1-Benzopyran-4-one, 2-(2-Amino-3-methoxyp

规格或纯度：≥98%

英文名称：PD98059

生化机理：PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1, blocking MEK-1 activation and leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells, it produced complete blockage of any increase in MAPK activity (IC50 = 2 μM) produced by nerve growth factor. It has been shown to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.Inhibitor of MKK1 (MEK1).

应用：A selective inhibitor of MEK and blocker of MAP

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PD98059是一种非ATP竞争性的MEK抑制剂，无细胞试验中IC50为2 μM，特异性抑制MEK-1介导的MAPK激活；不直接抑制ERK1或ERK2。A selective inhibitor of MEK and blocker of MAPPD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2.A selective inhibitor of MEK and blocker of MAP

IUPAC Name：2-(2-amino-3-methoxyphenyl)chromen-4-one

INCHI：InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChi Key：QFWCYNPOPKQOKV-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2

Isomeric SMILES：COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2

WGK Germany：3

PubChem CID：4713

CAS Registry No.：167869-21-8

ChEMBL Ligand：CHEMBL35482

溶解性：Soluble in DMSO (6.5 mg/ml), anhydrous DMSO (25 mg/ml), ethanol (0.6 mg/ml), dichloromethane, methanol, DMF (~20 mg/ml), and DMSOPBS (19 pH7.2) (~0.25 mg/ml). Insoluble in 2-hydroxypropyl-β-cyclodextrin, water, and dilute aqueous acid.

敏感性：对热敏感

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装