产品名称

英文名称：JDTic

同义词

JDTic、361444-66-8、Rti-jdtic、3C6FZ6UXC8、CHEMBL415247、(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide、(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-

产品性质

CAS编号：361444-66-8

分子式：C28H39N3O3

分子量：465.63

PubChem编号：9956146

英文别名：JDTic|361444-66-8|Rti-jdtic|3C6FZ6UXC8|CHEMBL415247|(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide|(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4-

英文名称：JDTic

生化机理：JDTic is a drμg that acts as an opioid antagonist, which is highly selective for the κ-opioid receptor. JDTic blocks this receptor without affecting the μ- or δ-opioid receptors. JDTic is a 4-phenylpiperidine derivative, distantly structurally related to analgesic drμgs such as meperidine and ketobemidone, and more closely to the mu opioid antagonist alvimopan, and is structurally distinct from other kappa antagonists such as norbinaltorphimine. JDTic has a very long duration of action, with effects in animals seen for up to several weeks after administration of a single dose, althoμgh its binding to the kappa opioid receptor is not irreversible and its long-acting effects are instead caused by altered activity of c-Jun N-terminal kinases. Animal studies sμggest that it may produce antidepressant and anxiolytic effects, as well as having possible application in the treatment of addiction to cocaine and morphine.

储存温度：-20°C储存

运输条件：超低温冰袋运输

IUPAC Name：(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

INCHI：InChI=1S/C28H39N3O3/c1-18(2)26(30-27(34)25-13-20-8-9-24(33)12-21(20)15-29-25)17-31-11-10-28(4,19(3)16-31)22-6-5-7-23(32)14-22/h5-9,12,14,18-19,25-26,29,32-33H,10-11,13,15-17H2,1-4H3,(H,30,34)/t19-,25+,26+,28+/m0/s1

InChi Key：ZLVXBBHTMQJRSX-VMGNSXQWSA-N

Canonical SMILES：CC1CN(CCC1(C)C2=CC(=CC=C2)O)CC(C(C)C)NC(=O)C3CC4=C(CN3)C=C(C=C4)O

Isomeric SMILES：C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)C[C@H](C(C)C)NC(=O)[C@H]3CC4=C(CN3)C=C(C=C4)O

PubChem CID：9956146

CAS Registry No.：361444-66-8

Wikipedia：JDTic

ChEMBL Ligand：CHEMBL415247

RCSB PDB Ligand：JDC

GPCRdb Ligand：JDTic

溶解性：DMSO

产品包装