产品名称

英文名称：CLP-290

同义词

[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate；CLP290、[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate；CLP290

产品性质

CAS编号：1181083-81-7

分子式：C19H21FN4O3S

分子量：404.46

MDL号：MFCD28166314

PubChem编号：44188755

别名：[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate；CLP290

英文别名：[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate；CLP290

规格或纯度：97%

英文名称：CLP-290

生化机理：K + / Cl-共转运蛋白2（KCC2）活化剂。激活脊髓抑制性中间神经元，恢复脊髓的生理神经元活性，并在小鼠脊髓损伤模型中诱导功能恢复。还可降低链脲佐菌素诱发的糖尿病小鼠的血管加压素和葡萄糖水平。CLP 257的口服生物可利用前药。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：CLP290 is a small molecule enhancer of KCC2 activity. It is an orally active and more bioavailable precursor of the selective K+-Cl- cotransporter KCC2 activator CLP257. CLP290 was recently shown to restore Cl- transport and rescue morphine-induced hyperalgesia (MIH) in morphine-treated ratsCLP290 is a small molecule enhancer of KCC2 activity. It is an orally active and more bioavailable precursor of the selective K+-Cl- cotransporter KCC2 activator CLP257. CLP290 was recently shown to restore Cl- transport and rescue morphine-induced hyperalgesia (MIH) in morphine-treated rats

IUPAC Name：[2-[(Z)-[2-(diazinan-1-yl)-4-oxo-1,3-thiazol-5-ylidene]methyl]-5-fluorophenyl] pyrrolidine-1-carboxylate

INCHI：InChI=1S/C19H21FN4O3S/c20-14-6-5-13(15(12-14)27-19(26)23-8-3-4-9-23)11-16-17(25)22-18(28-16)24-10-2-1-7-21-24/h5-6,11-12,21H,1-4,7-10H2/b16-11-

InChi Key：DIXMMXNNKLCLOM-WJDWOHSUSA-N

Canonical SMILES：C1CCN(NC1)C2=NC(=O)C(=CC3=C(C=C(C=C3)F)OC(=O)N4CCCC4)S2

Isomeric SMILES：C1CCN(NC1)C2=NC(=O)/C(=C/C3=C(C=C(C=C3)F)OC(=O)N4CCCC4)/S2

PubChem CID：44188755

溶解性：溶于DMSO, 最高浓度 (mg/mL) 20.22, 最高浓度(mM) 50；溶于ethanol, 最高浓度 (mg/mL) 2.02, 最高浓度(mM) 5

产品包装