产品名称

英文名称：Shikonin

同义词

shikonin、54952-43-1、SHIKALKIN、C.I. Natural Red 20、(+-)-Shikonin、Anchusin、(+/-)-Alkannin、ARNEBIN-4、(Rac)-Shikonin、5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione、Shikonine、C.I. 75530、NSC94524、(+)-Shikonin、NSC252844、NSC407295、23444-65-7

产品性质

CAS编号：54952-43-1

分子式：C16H16O5

分子量：288.3

PubChem编号：5208

英文别名：shikonin|54952-43-1|SHIKALKIN|C.I. Natural Red 20|(+-)-Shikonin|Anchusin|(+/-)-Alkannin|ARNEBIN-4|(Rac)-Shikonin|5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione|Shikonine|C.I. 75530|NSC94524|(+)-Shikonin|NSC252844|NSC407295|23444-65-7

规格或纯度：98% (HPLC)

英文名称：Shikonin

生化机理：Shikonin is a potent anti-fungal agent against C. albicans biofilms. It displays anti-oxidant and chemotherapeutic properties on human glioma cells. Naphthoquinone isolated from Arnebia sp. Used as an anti-inflammatory treatment in traditional chinese medicine (TCM). Inhibits chemokine receptor function and suppresses HIV-1.† Circumvents cancer drug resistance by induction of cell death through a necroptotic pathway.† Treatment of cancer cells with shikonin suppressed glycolysis via the inhibition of pyruvate kinase M2 (PKM2).

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Shikonin，是一种 Pyruvate kinase M2 (PKM2) 有效的、特异的抑制剂。它是紫草的主要成分，紫草是一种中草药，具有多种生物活性。在细胞荧光淬灭试验中，Shikonin也是TMEM16A氯离子通道的抑制剂。Shikonin 通过抑制 tumor necrosis factor-α (TNF-α) 发挥抗炎作用，并可通过抑制 proteasome 来阻止 nuclear factor-κB (NF-κB) 信号途径的激活。(±)-Shikonin is a racemic mixture of naturally occuring isohexenylnaphthazarin compounds which may contribute to antibacterial and anti-inflammatory activity.(±)-Shikonin is a racemic mixture of naturally occuring isohexenylnaphthazarin compounds which may contribute to antibacterial and anti-inflammatory activity.

IUPAC Name：5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione

INCHI：InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3

InChi Key：NEZONWMXZKDMKF-UHFFFAOYSA-N

Canonical SMILES：CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C

Isomeric SMILES：CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C

PubChem CID：5208

溶解性：methanol 1 mg/mL

敏感性：对热、湿度敏感

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH400 Very toxic to aquatic life

预防措施声明：P273,P501,P264,P270,P391,P330,P301+P317

产品包装