产品名称

英文名称：MG-132

同义词

MG-132、133407-82-6、Z-Leu-leu-leu-al、MG132、MG 132、Zlllal、Z-Leu-leu-leucinal、Z-LLL-CHO、Zlll-cho、Z-Leu-Leu-Leu-H、Carbobenzoxy-leucyl-leucyl-leucinal、C26H41N3O5、Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)am、MG132、蛋白酶体抑制剂、Z-LLL-CHO、碳苯并-L-亮氨酰-L-亮氨酰-L-亮氨酸

产品性质

CAS编号：133407-82-6

分子式：C26H41N3O5

分子量：475.62

PubChem编号：462382

别名：MG132|蛋白酶体抑制剂|Z-LLL-CHO|碳苯并-L-亮氨酰-L-亮氨酰-L-亮氨酸

英文别名：MG-132|133407-82-6|Z-Leu-leu-leu-al|MG132|MG 132|Zlllal|Z-Leu-leu-leucinal|Z-LLL-CHO|Zlll-cho|Z-Leu-Leu-Leu-H|Carbobenzoxy-leucyl-leucyl-leucinal|C26H41N3O5|Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)am

规格或纯度：≥98%

英文名称：MG-132

生化机理：MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. It is also an an inhibitor of calpain. MG-132 [Z-Leu-Leu-Leu-CHO] is an inhibitor of 26S Proteasome and an activator of JNK1, c-Jun and c-Fos.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：MG-132是一种蛋白酶体抑制剂，IC50为100 nM，也抑制钙蛋白酶，IC50为1.2 μM。A proteasome and NF-κB inhibitor.MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.A proteasome and NF-κB inhibitor.

IUPAC Name：benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

INCHI：InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChi Key：TZYWCYJVHRLUCT-VABKMULXSA-N

Canonical SMILES：CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

Isomeric SMILES：CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

PubChem CID：462382

溶解性：Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), chloroformmethanol solution (955) (10 mg/ml), water (<1 mg/ml), and DMF (~25 mg/ml).

敏感性：对热敏感

产品包装