产品名称

英文名称：Histamine, Free Base

同义词

2-Imidazol-4-ylethylamine 、 1H-Imidazole-4-ethanamine 、 2-(1H-imidazol-5-yl)ethanamine 、 2-(4-Imidazolyl)ethylamine、2-(4-咪唑基)乙胺

产品性质

CAS编号：51-45-6

分子式：C5H9N3

分子量：111.15

Beilstein号：2012

EC号：200-100-6

MDL号：MFCD00005210

PubChem编号：774

别名：2-(4-咪唑基)乙胺

英文别名：2-Imidazol-4-ylethylamine | 1H-Imidazole-4-ethanamine | 2-(1H-imidazol-5-yl)ethanamine | 2-(4-Imidazolyl)ethylamine

规格或纯度：96%

英文名称：Histamine, Free Base

生化机理：Histamine, Free Base is a potent vasodilator found in normal tissues and blood. This compound is formed by the decarboxylation of L-histidine and activates NOS (nitric oxide synthase), resulting in the release of nitric oxide. Activation of Histamine H1 Receptors leads to Ca2+ mobilization; whereas, Histamine H2 Receptor activation stimulates adenylate cyclase activity in neurons. Histamine inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.Potent vasodilator. Formed by the decarboxylation of L-histidine. Acts as an agonist for endogenous histamine receptors. Histamine H 1 receptor activation mobilizes Ca 2+ ; H 2 activation stimulates adenylate cyclase activity in neurons.

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：有吸湿性。在日光下易变质。组胺由组氨酸脱羧基形成，广泛分布在哺乳动物的组织中，尤其在肥大细胞及有关嗜碱性白细胞内(在变态反应中肥大细胞释放出组胺)。可以组氨酚为原料发酵制得。内源性H1 和 H2 组胺受体激动剂；H1 激活并使Ca2+移动；H2 激活并刺激神经元中腺苷酸环化酶(adenylate cyclase)活性；激活NO合成酶；血管扩张剂。A compound that activates NOS which results in the release of NO.

IUPAC Name：2-(1H-imidazol-5-yl)ethanamine

INCHI：InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

InChi Key：NTYJJOPFIAHURM-UHFFFAOYSA-N

Canonical SMILES：C1=C(NC=N1)CCN

Isomeric SMILES：C1=C(NC=N1)CCN

WGK Germany：3

RTECS：MS1050000

PubChem CID：774

UN Number：2811

溶解性：Soluble in water, alcohol, and hot chloroform.

密度：1.14

敏感性：易吸潮；对热、空气和光敏感

沸点：167°C

熔点：83-84°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowedH317 May cause an allergic skin reactionH334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P284,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319,P342+P316

个人防护装备：dust mask type N95 (US),Eyeshields,Faceshields,Gloves

产品包装