产品名称

英文名称：Thiolutin

同义词

Thiolutin、87-11-6、Acetopyrrothin、Acetopyrrothine、NSC3927、N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide、3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole、NSC-3927、Acetamide,N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrr

产品性质

CAS编号：87-11-6

分子式：C8H8N2O2S2

分子量：228.29

EC号：MFCD07370147

MDL号：MFCD07370147

PubChem编号：6870

英文别名：Thiolutin|87-11-6|Acetopyrrothin|Acetopyrrothine|NSC3927|N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide|3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole|NSC-3927|Acetamide,N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrr

规格或纯度：95%

英文名称：Thiolutin

生化机理：硫基抗生素剂。强大的RNA聚合酶抑制剂。抑制内皮细胞粘附（IC 50 = 0.83μM）。抑制肿瘤细胞诱导的血管生成，并在体内显示出抗肿瘤作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. The compound has been shown to inhibit transcription in Saccharomyces cerevisiae and mRNA degradation. Thiolutin inhibits the adhesion of endothelial cells, including adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin, and restricts tumor cell-induced angiogenesis. Studies have reported that Thiolutin is an effective inducer of HSP 27 (heat shock protein 27; Hsp27) phosphorylation. Research shows that in the presence of Thiolutin, the interaction between Hsp27 and nestin is disrupted, which results in the breakdown of nestin filaments.An RNA polymerase inhibitor and suppressor of tumor cell-induced angiogenesisThiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. The compound has been shown to inhibit transcription in Saccharomyces cerevisiae and mRNA degradation. Thiolutin inhibits the adhesion of endothelial cells, including adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin, and restricts tumor cell-induced angiogenesis. Studies have reported that Thiolutin is an effective inducer of HSP 27 (heat shock protein 27; Hsp27) phosphorylation. Research shows that in the presence of Thiolutin, the interaction between Hsp27 and nestin is disrupted, which results in the breakdown of nestin filaments.An RNA polymerase inhibitor and suppressor of tumor cell-induced angiogenesis

PubChem SID：488180184

IUPAC Name：N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide

INCHI：InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)

InChi Key：MHMRAFONCSQAIA-UHFFFAOYSA-N

Canonical SMILES：CC(=O)NC1=C2C(=CSS2)N(C1=O)C

Isomeric SMILES：CC(=O)NC1=C2C(=CSS2)N(C1=O)C

WGK Germany：3

RTECS：JP1355000

PubChem CID：6870

UN Number：2811

溶解性：Soluble in DMSO (5 mg/ml), and water (210 mg/L).

敏感性：对光敏感

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowed

预防措施声明：P321,P405,P501,P264,P270,P330,P301+P316

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装