产品名称

英文名称：Cetirizine

同义词

cetirizine、83881-51-0、Cetirizina、Cetryn、Ziptek、Setir、Cetirizinum、Cetirizin、Virlix、Hitrizin Film Tablet、Cetirizinum [Latin]、Cetiderm、2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid、AC-170、CETIRIZINE HYDROCHLORIDE、Cetirizine-D8、Cet

产品性质

CAS编号：83881-51-0

分子式：C21H25ClN2O3

分子量：388.89

PubChem编号：2678

英文别名：cetirizine|83881-51-0|Cetirizina|Cetryn|Ziptek|Setir|Cetirizinum|Cetirizin|Virlix|Hitrizin Film Tablet|Cetirizinum [Latin]|Cetiderm|2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid|AC-170|CETIRIZINE HYDROCHLORIDE|Cetirizine-D8|Cet

规格或纯度：98%

英文名称：Cetirizine

生化机理：Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。产品应用西替利嗪（CTZ）可用于皮肤肥大细胞增多症（色素性荨麻疹）的研究。西替利嗪是一种抗组胺药，可在过敏研究中用作组胺1受体（H1R）的拮抗剂。Product DescribtionCetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.

IUPAC Name：2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid

INCHI：InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)

InChi Key：ZKLPARSLTMPFCP-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl

Isomeric SMILES：C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl

PubChem CID：2678

ChEBI：CHEBI3561

CAS Registry No.：83881-51-0

Wikipedia：Cetirizine

ChEMBL Ligand：CHEMBL1000

DrugBank Ligand：DB00341

BindingDB Ligand：22890

PEP：cetirizine

DrugCentral Ligand：581

GPCRdb Ligand：cetirizine

溶解性：DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装