产品名称

英文名称：Eplerenone

同义词

6995V82D0B、D01115、HSDB 7522、DTXSID2046094、C03DA04、Epoxymexrenone、C24H30O6、Inspra (TN)、NCGC00159559-03、US9138393, 6-Chloropurine、UNII-6995V82D0B、DB00700、EPLERENONE [WHO-DD]、BE164415、CCG-268820、EPLERENONE (MART.)、EPLERENONE [MART.]、EPLERENONE [ORANGE、依普利酮

产品性质

CAS编号：107724-20-9

分子式：C24H30O6

分子量：414.49

MDL号：MFCD07783647

PubChem编号：443872

别名：依普利酮

英文别名：6995V82D0B|D01115|HSDB 7522|DTXSID2046094|C03DA04|Epoxymexrenone|C24H30O6|Inspra (TN)|NCGC00159559-03|US9138393, 6-Chloropurine|UNII-6995V82D0B|DB00700|EPLERENONE [WHO-DD]|BE164415|CCG-268820|EPLERENONE (MART.)|EPLERENONE [MART.]|EPLERENONE [ORANGE

规格或纯度：≥98%

英文名称：Eplerenone

生化机理：Eplerenone is an aldosterone antagonist with more specificity for the mineralocorticoid receptor (MCR) than spironolactone, having lower affinity for progesterone, androgen, and glucocorticoid receptors.Selective mineralocorticoid (aldosterone) antagonist (IC 50 = 81 nM). Significantly greater selectivity than spironolactone at androgen, progesterone and glucocorticoid receptors. Antihypertensive, orally active in vivo .

应用：An MCR antagonist.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Eplerenone是醛固酮拮抗剂，IC50为0.36 μM。An MCR antagonist.Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM.An MCR antagonist.

ALogP：1.4

IUPAC Name：methyl (1R,2S,9R,10R,11S,14R,15S,17R)-2,15-dimethyl-5,5'-dioxospiro[18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadec-6-ene-14,2'-oxolane]-9-carboxylate

INCHI：InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

InChi Key：JUKPWJGBANNWMW-VWBFHTRKSA-N

Canonical SMILES：CC12CCC(=O)C=C1CC(C3C24C(O4)CC5(C3CCC56CCC(=O)O6)C)C(=O)OC

Isomeric SMILES：C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5([C@H]3CC[C@@]56CCC(=O)O6)C)C(=O)OC

WGK Germany：3

PubChem CID：443872

DrugBank Ligand：DB00700

BindingDB Ligand：50324120

CAS Registry No.：107724-20-9

ChEBI：CHEBI31547

Wikipedia：Eplerenone

ChEMBL Ligand：CHEMBL1095097

PEP：eplerenone

RCSB PDB Ligand：YNU, YNU

DrugCentral Ligand：1032

溶解性：Soluble in DMSO (10 mM), water (very slightly), ethanol (slightly), methanol (sparingly), and chloroform.

敏感性：对热敏感

熔点：242 °C(dec.)

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowedH317 May cause an allergic skin reactionH312 Harmful in contact with skinH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P272,P333+P313,P362+P364,P330,P203,P301+P317,P318,P317,P319

Merck Index：3625

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装