产品名称

英文名称：Nobiletin

同义词

SPBio_001654、NC00186、Spectrum3_000921、2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one、GTPL12446、HMS2234A09、MFCD03273560、AKOS015965334、FT-0686667、MLS000759462、NSC76751、2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one、D65ILJ7、蜜橘黄素

产品性质

CAS编号：478-01-3

分子式：C21H22O8

分子量：402.39

Beilstein号：360887

MDL号：MFCD03273560

PubChem编号：72344

别名：蜜橘黄素

英文别名：SPBio_001654|NC00186|Spectrum3_000921|2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one|GTPL12446|HMS2234A09|MFCD03273560|AKOS015965334|FT-0686667|MLS000759462|NSC76751|2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one|D65ILJ7

规格或纯度：分析标准品

英文名称：Nobiletin

生化机理：Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.

应用：An antioxidant and anti-inflammatory that Inhibits the phosphorylation of MEK.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Nobiletin is a flavanoid with antioxidant and anti-inflammatory properties found in the rind of tangerines. The compound has been observed to inhibit the phosphorylation of MEK (mitogen-activated protein kinase). Nobiletin has also been documented to suppress the expression of MMP-1 (matrix metalloproteinases), MMP-3 and MMP-9 that are involved in the breakdown of the extracellular matrix during tumor metastasis. In vitro studies of Nobiletin on varying cancer cell lines and on the chick egg has shown the anti-angiogenic effects of Nobiletin throμgh down regulation of ERK 1, ERK 2 and c-Jun N-terminal kinase, and transcriptional factors c-Jun and Stat3. The compound also suppressed proliferation, migration and tube formation on matrigel of HUVEC cells stimulated with growth supplement. Nobiletin has demonstrated to attenuate NF-κB transcriptional activation, NO and PGE2 production, NOS2 (inducible nitric oxide synthase) and Cox-2 (cyclooxygenase-2) expression.An antioxidant and anti-inflammatory that Inhibits the phosphorylation of MEK.Nobiletin is a flavanoid with antioxidant and anti-inflammatory properties found in the rind of tangerines. The compound has been observed to inhibit the phosphorylation of MEK (mitogen-activated protein kinase). Nobiletin has also been documented to suppress the expression of MMP-1 (matrix metalloproteinases), MMP-3 and MMP-9 that are involved in the breakdown of the extracellular matrix during tumor metastasis. In vitro studies of Nobiletin on varying cancer cell lines and on the chick egg has shown the anti-angiogenic effects of Nobiletin through down regulation of ERK 1, ERK 2 and c-Jun N-terminal kinase, and transcriptional factors c-Jun and Stat3. The compound also suppressed proliferation, migration and tube formation on matrigel of HUVEC cells stimulated with growth supplement. Nobiletin has demonstrated to attenuate NF-κB transcriptional activation, NO and PGE2 production, NOS2 (inducible nitric oxide synthase) and Cox-2 (cyclooxygenase-2) expression.An antioxidant and anti-inflammatory that Inhibits the phosphorylation of MEK.

IUPAC Name：2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

INCHI：InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3

InChi Key：MRIAQLRQZPPODS-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

Isomeric SMILES：COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

WGK Germany：3

RTECS：DJ3052200

关联CAS：478-01-3

PubChem CID：72344

NSC Number：76751

MeSH Entry Terms：hexamethoxyflavone;nobiletin

Reaxy-Rn：360887

溶解性：Soluble in methanol ( ), water (<1 mg/ml), chloroform, DMSO (81 mg/ml), and ethanol (3 mg/ml).

敏感性：对热敏感

熔点：138°C

产品包装