产品名称

英文名称：Lenalidomide

同义词

Lenalidomide、191732-72-6、Revlimid、Revimid、3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione、CC-5013、CDC 501、CDC-501、Lenalidomide (CC-5013)、3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione、IMiD3、2,6-Piperidinedione, 3-(4-amino-1,3-dihy、来那度胺、3-(4-氨基-1,3-二氢-1-氧代-2H-异吲哚-2-基)-2,6-哌啶二酮、3-(4-氨基-1-异吲哚啉-2-基)哌啶-2,6-二酮、3-(4-氨基-1-氧代异吲哚-2-基)哌啶-2,6-二酮、CC-5013、1-氧-4-氨基-2-(2,6-二氧哌啶-3-基)异吲哚

产品性质

CAS编号：191732-72-6

分子式：C13H13N3O3

分子量：259.27

EC号：691-297-1

PubChem编号：216326

别名：来那度胺|3-(4-氨基-1,3-二氢-1-氧代-2H-异吲哚-2-基)-2,6-哌啶二酮|3-(4-氨基-1-异吲哚啉-2-基)哌啶-2,6-二酮|3-(4-氨基-1-氧代异吲哚-2-基)哌啶-2,6-二酮|CC-5013|1-氧-4-氨基-2-(2,6-二氧哌啶-3-基)异吲哚

英文别名：Lenalidomide|191732-72-6|Revlimid|Revimid|3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione|CC-5013|CDC 501|CDC-501|Lenalidomide (CC-5013)|3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione|IMiD3|2,6-Piperidinedione, 3-(4-amino-1,3-dihy

规格或纯度：≥99%

英文名称：Lenalidomide

生化机理：Lenalidomide is a thalidomide analog known to inhibit TNF-α secretion and possess immunomodulatory properties.Thalidomide analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Lenalidomide (CC-5013)是Thalidomide的衍生物，是一种TNF-α分泌抑制剂，IC50为13 nM。 A Thalidomide analog known to have immunomodulatory propertiesLenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.A Thalidomide analog known to have immunomodulatory properties

ALogP：-0.5

IUPAC Name：3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

INCHI：InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChi Key：GOTYRUGSSMKFNF-UHFFFAOYSA-N

Canonical SMILES：C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

Isomeric SMILES：C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

关联CAS：191732-72-6

PubChem CID：216326

NSC Number：747972

MeSH Entry Terms：2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H- isoindol-2-yl)-;3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;CC 5013;CC-5013;CC5013;IMiD3 cpd;lenalidomide;Revimid;Revlimid

DrugBank Ligand：DB00480

CAS Registry No.：191732-72-6

ChEMBL Ligand：CHEMBL848

Wikipedia：Lenalidomide

Reactome Reaction：R-HSA-9681169

Reactome Drug：R-ALL-9681174

DrugCentral Ligand：3317

溶解性：Soluble in DMSO (≥52 mg/ml) at 25 °C, methanol and water (2 1), buffered aqueous solvents, water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C.

敏感性：对热敏感

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P362+P364,P330,P203,P301+P316,P301+P317,P318,P317,P319

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